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> Protein (NX_P17252)
Protein (NX_P17252)
Protein
Gene SymbolPRKCA to neXtProt (NX_P17252)
DescriptionProtein kinase C alpha type
Chromosome17
Location17q24.2 (64298754 ~ 64806861) to Ensembl
Sequene Features : Isoforms 1, Variants 80, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of dense core granule biogenesis
.intrinsic apoptotic signaling pathway
.apoptotic signaling pathway
  + 56 more...
.histone kinase activity (H3-T6 specific)
.enzyme binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 80 14
2014-09-19protein level
1 56 14
2014-05-27protein level
1 56 18
2014-02-25protein level
1 56 18
2013-12-09protein level
1 52 18
2013-11-01protein level
1 46 16
2013-09-12protein level
1 46 16
2013-08-17protein level
1 46 16
2013-07-15protein level
1 36 11
2013-06-11protein level
1 36 11
2013-02-12protein level
1 18 17
2012-12-20protein level
1 18 17
2012-10-30protein level
1 18 17
2012-10-07protein level
1 18 17
2012-08-24protein level
1 17 17
2012-07-28protein level
1 17 17
2012-06-08protein level
1 20 17
2012-05-07protein level
1 9 17
2012-04-10protein level
1 9 17
2012-01-13protein level
1 7 17
2011-12-20protein level
1 7 16
2011-11-11protein level
1 7 15
2011-08-23protein level
1 7 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P17252-1
20 0 10 76699.9143
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383528,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1383528,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-1383528,EBI-3913237 SDC4  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.positive regulation of focal adhesion assembly
  + 13 more...
.thrombospondin receptor activity .extracellular exosome
.membrane raft
.lysosomal lumen
  + 6 more...
4 EBI-1383528,EBI-301697 HDAC6  
  .positive regulation of hydrogen peroxide-mediated programmed cell death
.tubulin deacetylation
.positive regulation of chaperone-mediated protein complex assembly
  + 38 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.dynein complex binding
.Hsp90 protein binding
  + 16 more...
.perinuclear region of cytoplasm
.perikaryon
.cell leading edge
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood8
brain21
connective tissue13
eye38
intestine8
kidney18
liver24
mammary gland13
muscle9
nerve128
ovary9
pancreas4
prostate10
skin4
stomach10
thyroid21
uterus17
vascular19
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor21
gastrointestinal tumor16
glioma55
kidney tumor29
leukemia10
liver tumor52
non-neoplasia20
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer19
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult35
neonate32
fetus43
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland15.8
appendix7.7
bone marrow2
cerebral cortex26.3
colon9.5
duodenum11.2
esophagus3.8
gallbladder9.4
heart muscle3.8
kidney14.2
liver3.2
lung5.3
lymph node5.6
ovary16.4
pancreas2.1
placenta4.5
prostate10.4
salivary gland1.7
skin2.6
small intestine10.4
spleen6.7
stomach6.2
testis4.3
thyroid gland4
urinary bladder10.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumLow
epididymisLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lymph nodeLow
pancreasMedium
placentaLow
rectumLow
skeletal muscleLow
skin 1Low
small intestineLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176960, gene) Protein kinase c, alpha; PRKCAOMIM


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