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> Protein (NX_P17706)
Protein (NX_P17706)
Protein
Gene SymbolPTPN2 to neXtProt (NX_P17706)
DescriptionTyrosine-protein phosphatase non-receptor type 2
Chromosome18
Location18p11.21 (12785477 ~ 12929642) to Ensembl
Sequene Features : Isoforms 4, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of platelet-derived growth factor receptor-beta signaling pathway
.negative regulation of positive thymic T cell selection
.negative regulation of macrophage colony-stimulating factor signaling pathway
  + 31 more...
.receptor tyrosine kinase binding
.syntaxin binding
.protein kinase binding
  + 2 more...
.plasma membrane
.endoplasmic reticulum-Golgi intermediate compartment
.endoplasmic reticulum
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 47 4
2014-09-19protein level
4 36 4
2014-05-27protein level
4 36 4
2014-02-25protein level
3 36 4
2013-12-09protein level
3 34 4
2013-11-01protein level
3 34 4
2013-09-12protein level
3 34 4
2013-08-17protein level
3 34 4
2013-07-15protein level
3 17 2
2013-06-11protein level
3 17 2
2013-02-12protein level
3 9 12
2012-12-20protein level
3 9 12
2012-10-30protein level
3 9 12
2012-10-07protein level
3 9 4
2012-08-24protein level
3 8 4
2012-07-28protein level
3 8 4
2012-06-08protein level
3 9 4
2012-05-07protein level
3 9 4
2012-04-10protein level
2 9 4
2012-01-13protein level
2 6 4
2011-12-20protein level
2 6 4
2011-11-11protein level
2 6 4
2011-08-23protein level
2 6 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P17706-1
2 15 0 48442.2424
NX_P17706-2
0 15 0 45139.5294
NX_P17706-3
1 14 0 40964.1906
NX_P17706-4
1 14 0 47986.1707
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-984930,EBI-286316 GHR  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
2 EBI-4409481,EBI-998422 TMED10  
  .regulation of beta-amyloid formation
.protein oligomerization
.COPII vesicle coating
  + 11 more...
.syntaxin binding .gamma-secretase complex
.extracellular exosome
.zymogen granule membrane
  + 14 more...
3 EBI-4409481,EBI-1056827 TMED9  
  .COPI coating of Golgi vesicle
.protein transport
.positive regulation of organelle organization
.Golgi organization
.syntaxin binding .extracellular exosome
.endoplasmic reticulum-Golgi intermediate compartment membrane
.trans-Golgi network transport vesicle
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
bone139
brain26
cervix41
connective tissue73
ear62
embryonic tissue46
esophagus49
eye71
heart122
intestine17
kidney23
larynx42
liver53
lung2
lymph node89
mammary gland66
mouth15
muscle28
ovary9
pancreas28
pharynx24
pituitary gland60
placenta60
prostate36
skin18
spleen18
stomach31
testis32
thymus50
trachea38
uterus43
vascular38
Health State
TissuesTPM*
normal47
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma169
colorectal tumor79
esophageal tumor57
gastrointestinal tumor16
germ cell tumor26
glioma18
head and neck tumor22
kidney tumor43
leukemia10
liver tumor62
lymphoma13
non-neoplasia31
ovarian tumor13
pancreatic tumor47
primitive neuroectodermal tumor of the CNS55
prostate cancer57
retinoblastoma64
skin tumor7
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult1
embryoid body42
blastocyst16
fetus78
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.6
adrenal gland14.1
appendix32.8
bone marrow29
cerebral cortex7.9
colon17
duodenum14.1
esophagus10.3
gallbladder17.8
heart muscle6.5
kidney11
liver11.7
lung17.8
lymph node35.3
ovary21.7
pancreas9.4
placenta13.8
prostate11.3
salivary gland11.7
skin17
small intestine14.5
spleen24.2
stomach14.5
testis11.9
thyroid gland12.7
urinary bladder18.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176887, gene) Protein-tyrosine phosphatase, nonreceptor-type, 2; PTPN2OMIM


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