Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P17948)
Protein (NX_P17948)
Protein
Gene SymbolFLT1 to neXtProt (NX_P17948)
DescriptionVascular endothelial growth factor receptor 1
Chromosome13
Location13q12.2 (28874489 ~ 29069265) to Ensembl
Sequene Features : Isoforms 8, Variants 264, PTMs 28 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 264 28
2014-09-19protein level
8 202 28
2014-05-27protein level
8 202 28
2014-02-25protein level
8 198 28
2013-12-09protein level
8 176 28
2013-11-01protein level
8 164 28
2013-09-12protein level
8 164 28
2013-08-17protein level
7 164 28
2013-07-15protein level
7 115 28
2013-06-11protein level
7 115 28
2013-02-12protein level
7 52 104
2012-12-20protein level
7 52 104
2012-10-30protein level
7 61 104
2012-10-07protein level
7 61 29
2012-08-24protein level
7 32 29
2012-07-28protein level
7 32 29
2012-06-08protein level
7 20 29
2012-05-07protein level
7 20 29
2012-04-10protein level
7 20 29
2012-01-13protein level
7 20 29
2011-12-20protein level
7 20 29
2011-11-11protein level
7 20 29
2011-08-23protein level
2 16 27
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P17948-1
4 57 2 150672.0794
NX_P17948-2
1 32 0 77424.6702
NX_P17948-3
1 34 0 82071.7066
NX_P17948-4
1 24 0 60878.1193
NX_P17948-5
0 23 2 62913.2051
NX_P17948-6
0 20 2 52578.8729
NX_P17948-7
1 12 2 39123.2099
NX_P17948-8
1 13 2 41148.1447
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1026718,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
2 EBI-1026718,EBI-1026643 VEGFA  
  .positive regulation of protein kinase D signaling
.positive regulation of protein localization to early endosome
.positive regulation of retinal ganglion cell axon guidance
  + 95 more...
.extracellular matrix binding
.receptor agonist activity
.protein heterodimerization activity
  + 12 more...
.platelet alpha granule lumen
.secretory granule
.membrane
  + 5 more...
3 EBI-1026718,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
4 EBI-1026718,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
5 EBI-1026718,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
6 EBI-1026718,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
7 EBI-1026718,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
8 EBI-1026718,EBI-1037633 PGF  
  .regulation of morphogenesis of a branching structure
.positive regulation of cell division
.vascular endothelial growth factor receptor signaling pathway
  + 13 more...
.heparin binding
.growth factor activity
.membrane
.extracellular space
.extracellular region
9 EBI-6530464,EBI-6896607 HSPG2  
  .cartilage development involved in endochondral bone morphogenesis
.cardiac muscle tissue development
.embryonic skeletal system morphogenesis
  + 16 more...
.metal ion binding
.protein C-terminus binding
.extracellular exosome
.lysosomal lumen
.extracellular matrix
  + 6 more...
10 EBI-1026718,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
11 EBI-1026718,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
12 EBI-1026718,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood16
bone13
brain25
connective tissue67
embryonic tissue28
eye90
heart22
intestine8
kidney61
liver9
lung23
mammary gland13
muscle28
nerve128
ovary19
pancreas56
parathyroid194
placenta484
prostate26
skin9
spleen18
stomach20
testis43
thymus12
thyroid107
trachea19
uterus94
vascular38
Health State
TissuesTPM*
normal92
chondrosarcoma84
gastrointestinal tumor16
germ cell tumor15
glioma9
head and neck tumor37
kidney tumor14
liver tumor20
lymphoma13
non-neoplasia10
pancreatic tumor28
skin tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult111
embryoid body14
blastocyst32
fetus57
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.7
adrenal gland6.1
appendix6.5
cerebral cortex7.7
colon4.1
duodenum4.7
esophagus4.8
gallbladder14.4
heart muscle16.8
kidney13.9
liver9.2
lung10.8
lymph node3.7
ovary2.1
pancreas3.9
placenta346.8
prostate5.7
salivary gland3.4
skin2.6
small intestine3.9
spleen14.6
stomach7.4
testis5.5
thyroid gland38.3
urinary bladder7.1
Tissues
TissuesExpression level
cerebral cortexLow
colonMedium
gallbladderLow
heart muscleLow
placentaMedium
skeletal muscleLow
smooth muscleMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*165070, gene) Fms-related tyrosine kinase 1; FLT1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2020 (C) Yonsei Proteome Research Center