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> Protein (NX_P17980)
Protein (NX_P17980)
Protein
Gene SymbolPSMC3 to neXtProt (NX_P17980)
Description26S protease regulatory subunit 6A
Chromosome11
Location11p11.2 (47440320 ~ 47447993) to Ensembl
Sequene Features : Isoforms 1, Variants 46, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nucleic acid-templated transcription
.positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
  + 26 more...
.proteasome-activating ATPase activity
.TBP-class protein binding
.ATPase activity
  + 3 more...
.perinuclear region of cytoplasm
.cytosolic proteasome complex
.nuclear proteasome complex
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 46 24
2014-09-19protein level
1 30 24
2014-05-27protein level
1 30 24
2014-02-25protein level
1 30 24
2013-12-09protein level
1 28 24
2013-11-01protein level
1 26 21
2013-09-12protein level
1 26 21
2013-08-17protein level
1 26 21
2013-07-15protein level
1 18 2
2013-06-11protein level
1 18 2
2013-02-12protein level
1 9 2
2012-12-20protein level
1 9 2
2012-10-30protein level
1 10 2
2012-10-07protein level
1 10 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 10 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 11 2
2011-12-20protein level
1 11 2
2011-11-11protein level
1 11 2
2011-08-23protein level
1 11 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P17980-1
21 0 0 49172.3149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359720,EBI-750973 PSMD9  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 26 more...
.bHLH transcription factor binding
.transcription coactivator activity
.proteasome regulatory particle
.cytosol
.cytoplasm
  + 2 more...
2 EBI-359720,EBI-357669 PSMC6  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.proteasome-activating ATPase activity
.protein binding, bridging
.TBP-class protein binding
  + 2 more...
.extracellular exosome
.cytosolic proteasome complex
.nuclear proteasome complex
  + 7 more...
3 EBI-359720,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland121
ascites225
bladder66
blood130
bone265
bone marrow143
brain92
cervix556
connective tissue33
embryonic tissue277
esophagus446
eye167
heart111
intestine168
kidney166
larynx170
liver253
lung244
lymph902
lymph node77
mammary gland224
mouth15
muscle244
nerve257
ovary246
pancreas103
pharynx147
pituitary gland60
placenta148
prostate253
salivary gland1036
skin251
spleen37
stomach156
testis34
thymus50
thyroid279
tonsil235
umbilical cord145
uterus120
vascular271
Health State
TissuesTPM*
normal94
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor311
cervical tumor666
chondrosarcoma132
colorectal tumor159
esophageal tumor521
gastrointestinal tumor219
germ cell tumor163
glioma130
head and neck tumor254
kidney tumor217
leukemia158
liver tumor385
lung tumor593
lymphoma595
non-neoplasia31
ovarian tumor236
pancreatic tumor199
primitive neuroectodermal tumor of the CNS377
prostate cancer404
retinoblastoma323
skin tumor382
soft tissue/muscle tissue tumor175
uterine tumor155
Developmental Stage
TissuesTPM*
adult133
embryoid body285
blastocyst244
neonate64
fetus73
infant425
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue71.8
adrenal gland59.8
appendix65.8
bone marrow56.3
cerebral cortex75.1
colon78.8
duodenum45.3
esophagus71
gallbladder51.4
heart muscle95.9
kidney64.5
liver69.2
lung57.2
lymph node65.5
ovary52.1
pancreas28.9
placenta90.3
prostate54.5
salivary gland47.4
skin73.5
small intestine44.9
spleen49.6
stomach52
testis63.2
thyroid gland68.9
urinary bladder66.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*186852, gene) Proteasome 26s subunit, atpase, 3; PSMC3OMIM


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