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> Protein (NX_P18031)
Protein (NX_P18031)
Protein
Gene SymbolPTPN1 to neXtProt (NX_P18031)
DescriptionTyrosine-protein phosphatase non-receptor type 1
Chromosome20
Location20q13.13 (49126891 ~ 49201299) to Ensembl
Sequene Features : Isoforms 1, Variants 49, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 49 15
2014-09-19protein level
1 38 13
2014-05-27protein level
1 38 13
2014-02-25protein level
1 36 13
2013-12-09protein level
1 30 13
2013-11-01protein level
1 29 13
2013-09-12protein level
1 29 14
2013-08-17protein level
1 29 14
2013-07-15protein level
1 20 14
2013-06-11protein level
1 20 14
2013-02-12protein level
1 12 15
2012-12-20protein level
1 12 15
2012-10-30protein level
1 14 15
2012-10-07protein level
1 14 15
2012-08-24protein level
1 13 15
2012-07-28protein level
1 13 15
2012-06-08protein level
1 16 15
2012-05-07protein level
1 12 14
2012-04-10protein level
1 12 14
2012-01-13protein level
1 4 12
2011-12-20protein level
1 4 12
2011-11-11protein level
1 4 12
2011-08-23protein level
1 4 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18031-1
23 0 0 49934.6789
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-968788,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
2 EBI-968788,EBI-518647 JAK2  
  .activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.response to interleukin-12
  + 76 more...
.histone binding
.SH2 domain binding
.histone kinase activity (H3-Y41 specific)
  + 9 more...
.membrane raft
.endosome lumen
.extrinsic component of cytoplasmic side of plasma membrane
  + 7 more...
3 EBI-968788,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-968788,EBI-1028226 NTRK1  
  .cellular response to nerve growth factor stimulus
.cellular response to nicotine
.positive regulation of ERK1 and ERK2 cascade
  + 41 more...
.nerve growth factor binding
.neurotrophin binding
.protein homodimerization activity
  + 3 more...
.receptor complex
.protein complex
.neuronal cell body
  + 11 more...
5 EBI-968788,EBI-702847 ITGB3  
  .platelet aggregation
.angiogenesis involved in wound healing
.negative chemotaxis
  + 35 more...
.extracellular matrix binding
.cell adhesion molecule binding
.vascular endothelial growth factor receptor 2 binding
  + 6 more...
.alphav-beta3 integrin-vitronectin complex
.extracellular exosome
.receptor complex
  + 13 more...
6 EBI-968788,EBI-703066 ITGB1  
  .negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
7 EBI-968788,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
8 EBI-968788,EBI-1542113 CAPN1  
  .receptor catabolic process
.extracellular matrix organization
.extracellular matrix disassembly
  + 2 more...
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.extracellular exosome
.membrane
.focal adhesion
  + 3 more...
9 EBI-968788,EBI-475981 IGF1R  
  .positive regulation of steroid hormone biosynthetic process
.prostate gland epithelium morphogenesis
.negative regulation of protein kinase B signaling
  + 30 more...
.insulin receptor substrate binding
.insulin binding
.phosphatidylinositol 3-kinase binding
  + 7 more...
.receptor complex
.intracellular membrane-bounded organelle
.neuron projection
  + 4 more...
10 EBI-968788,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
11 EBI-968788,EBI-7371065 ROS1  
  .regulation of ERK1 and ERK2 cascade
.regulation of TOR signaling
.cell differentiation
  + 9 more...
.protein phosphatase binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.protein tyrosine kinase activity
.integral component of membrane
.membrane
.plasma membrane
12 EBI-968788,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
13 EBI-968788,EBI-594644 TXN  
  .negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
14 EBI-968788,EBI-286316 GHR  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
15 EBI-968788,EBI-8658094 BCR  
  .regulation of cell cycle
.regulation of small GTPase mediated signal transduction
.neuromuscular process controlling balance
  + 15 more...
.kinase activity
.ATP binding
.GTPase activator activity
  + 3 more...
.extracellular exosome
.postsynaptic membrane
.protein complex
  + 4 more...
16 EBI-968788,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
17 EBI-968788,EBI-617321 EPOR  
  .decidualization
.erythropoietin-mediated signaling pathway
.heart development
  + 2 more...
.identical protein binding
.erythropoietin receptor activity
.integral component of plasma membrane
.extracellular region
18 EBI-968788,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
19 EBI-968788,EBI-749537 STAT5A  
  .cellular response to granulocyte macrophage colony-stimulating factor stimulus
.positive regulation of mast cell proliferation
.mammary gland epithelium development
  + 45 more...
.signal transducer activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter sequence-specific DNA binding
.cytosol
.nucleoplasm
20 EBI-968788,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
21 EBI-968788,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
22 EBI-968788,EBI-603614 CAV1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
23 EBI-968788,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
24 EBI-968788,EBI-1056589 RMDN3  
  .cell differentiation
.apoptotic process
.cellular calcium ion homeostasis
.N/A .integral component of membrane
.microtubule
.mitochondrial outer membrane
  + 3 more...
25 EBI-968788,EBI-7198335 TRPV6  
  .calcium ion transmembrane transport
.transmembrane transport
.ion transmembrane transport
  + 2 more...
.calmodulin binding
.calcium channel activity
.extracellular exosome
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder33
blood81
bone55
bone marrow61
brain89
cervix41
connective tissue93
embryonic tissue51
esophagus49
eye47
heart44
intestine77
kidney156
larynx42
liver77
lung65
lymph67
lymph node77
mammary gland59
mouth529
muscle47
nerve64
ovary19
pancreas32
parathyroid48
placenta137
prostate58
salivary gland98
skin52
spleen112
stomach10
testis140
thymus414
thyroid257
tonsil58
trachea289
uterus73
vascular77
Health State
TissuesTPM*
normal81
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma60
colorectal tumor44
esophageal tumor57
gastrointestinal tumor33
germ cell tumor155
glioma93
head and neck tumor373
kidney tumor58
leukemia84
liver tumor104
lung tumor38
lymphoma41
non-neoplasia124
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer38
retinoblastoma43
skin tumor55
uterine tumor33
Developmental Stage
TissuesTPM*
adult82
embryoid body57
blastocyst81
fetus127
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.7
adrenal gland22.5
appendix43.9
bone marrow33.7
cerebral cortex11.9
colon19.4
duodenum12.5
esophagus25.1
gallbladder26.5
heart muscle18.9
kidney17.6
liver9.9
lung38.1
lymph node52.2
ovary18.5
pancreas8
placenta32.4
prostate19.7
salivary gland9.5
skin16.1
small intestine12.6
spleen32.4
stomach18.3
testis21
thyroid gland16.4
urinary bladder29.3
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
kidneyMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasLow
parathyroid glandLow
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176885, gene) Protein-tyrosine phosphatase, nonreceptor-type, 1; PTPN1OMIM


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