Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P18206)
Protein (NX_P18206)
Protein
Gene SymbolVCL to neXtProt (NX_P18206)
DescriptionVinculin
Chromosome10
Location10q22.2 (75757872 ~ 75879918) to Ensembl
Sequene Features : Isoforms 3, Variants 99, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.epithelial cell-cell adhesion
.platelet aggregation
.axon extension
  + 13 more...
.cadherin binding
.alpha-catenin binding
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.membrane raft
.protein complex
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 99 30
2014-09-19protein level
3 79 30
2014-05-27protein level
3 79 30
2014-02-25protein level
3 77 30
2013-12-09protein level
3 66 30
2013-11-01protein level
3 61 21
2013-09-12protein level
3 61 23
2013-08-17protein level
3 61 23
2013-07-15protein level
3 37 23
2013-06-11protein level
3 37 23
2013-02-12protein level
3 22 38
2012-12-20protein level
3 20 38
2012-10-30protein level
3 28 38
2012-10-07protein level
3 28 18
2012-08-24protein level
3 28 18
2012-07-28protein level
3 28 18
2012-06-08protein level
3 6 18
2012-05-07protein level
3 6 18
2012-04-10protein level
3 6 18
2012-01-13protein level
3 6 18
2011-12-20protein level
3 12 18
2011-11-11protein level
3 12 18
2011-08-23protein level
3 12 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18206-1
1 63 0 123721.4533
NX_P18206-2
0 63 0 116648.9826
NX_P18206-3
2 11 0 24887.999
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716775,EBI-352356 ARPC2  
  .positive regulation of substrate adhesion-dependent cell spreading
.ephrin receptor signaling pathway
.innate immune response
  + 6 more...
.structural constituent of cytoskeleton .extracellular exosome
.synapse
.neuron projection
  + 9 more...
2 EBI-716775,EBI-10180409 TEKT1  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
ascites426
bladder167
blood106
bone321
bone marrow246
brain86
cervix41
connective tissue134
ear248
embryonic tissue389
esophagus198
eye90
heart111
intestine176
kidney142
larynx255
liver102
lung131
lymph node200
mammary gland145
mouth453
muscle150
nerve64
ovary226
pancreas117
parathyroid97
pharynx73
placenta215
prostate153
salivary gland197
skin99
spleen93
stomach125
testis259
thyroid107
trachea579
uterus435
vascular174
Health State
TissuesTPM*
normal157
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma217
colorectal tumor195
esophageal tumor231
gastrointestinal tumor253
germ cell tumor205
glioma27
head and neck tumor291
kidney tumor203
leukemia243
liver tumor145
lung tumor97
non-neoplasia103
ovarian tumor223
pancreatic tumor142
primitive neuroectodermal tumor of the CNS23
prostate cancer192
skin tumor23
soft tissue/muscle tissue tumor87
uterine tumor166
Developmental Stage
TissuesTPM*
adult201
embryoid body443
blastocyst520
fetus129
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.9
adrenal gland21.2
appendix57.3
bone marrow29.6
cerebral cortex10.3
colon76.5
duodenum34.1
esophagus94.7
gallbladder82.2
heart muscle109
kidney34.4
liver18.2
lung59.5
lymph node20.8
ovary47.9
pancreas21.7
placenta73.4
prostate105.7
salivary gland25.4
skin25.1
small intestine35.5
spleen41.1
stomach32.2
testis53.5
thyroid gland45.1
urinary bladder95.2
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
kidneyMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*193065, gene) Vinculin; VCLOMIM
2(#611407, phenotype) Cardiomyopathy, dilated, 1w; CMD1WOMIM
3(#613255, phenotype) Cardiomyopathy, familial hypertrophic, 15; CMH15OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2018 (C) Yonsei Proteome Research Center