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> Protein (NX_P18433)
Protein (NX_P18433)
Protein
Gene SymbolPTPRA to neXtProt (NX_P18433)
DescriptionReceptor-type tyrosine-protein phosphatase alpha
Chromosome20
Location20p13 (2844830 ~ 3019722) to Ensembl
Sequene Features : Isoforms 4, Variants 83, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.insulin receptor signaling pathway
.axon guidance
.protein phosphorylation
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.receptor complex
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 83 11
2014-09-19protein level
4 53 11
2014-05-27protein level
4 53 11
2014-02-25protein level
4 53 11
2013-12-09protein level
4 40 11
2013-11-01protein level
4 38 11
2013-09-12protein level
4 38 10
2013-08-17protein level
4 38 10
2013-07-15protein level
4 23 10
2013-06-11protein level
4 23 10
2013-02-12protein level
4 14 42
2012-12-20protein level
4 13 42
2012-10-30protein level
4 19 42
2012-10-07protein level
4 19 11
2012-08-24protein level
4 19 11
2012-07-28protein level
4 19 11
2012-06-08protein level
4 7 11
2012-05-07protein level
4 7 11
2012-04-10protein level
4 7 11
2012-01-13protein level
4 7 11
2011-12-20protein level
4 7 11
2011-11-11protein level
4 7 11
2011-08-23protein level
4 7 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18433-1
0 36 3 90542.1755
NX_P18433-2
1 35 3 89572.694
NX_P18433-3
2 34 3 90661.2445
NX_P18433-4
0 35 3 89645.7681
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2609645,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
2 EBI-2609645,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites125
bladder33
blood204
bone111
bone marrow123
brain145
cervix82
connective tissue73
embryonic tissue164
esophagus49
eye172
heart67
intestine133
kidney75
larynx127
liver58
lung140
lymph112
lymph node100
mammary gland191
mouth15
muscle84
nerve193
ovary226
pancreas74
parathyroid194
pharynx24
pituitary gland242
placenta21
prostate168
salivary gland49
skin147
spleen112
stomach104
testis78
thymus62
thyroid128
uterus112
vascular96
Health State
TissuesTPM*
normal110
adrenal tumor237
bladder carcinoma284
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma156
colorectal tumor115
esophageal tumor57
gastrointestinal tumor118
germ cell tumor83
glioma186
head and neck tumor82
kidney tumor87
leukemia285
liver tumor72
lung tumor204
lymphoma152
non-neoplasia124
ovarian tumor157
pancreatic tumor114
primitive neuroectodermal tumor of the CNS149
prostate cancer96
retinoblastoma86
skin tumor167
soft tissue/muscle tissue tumor55
uterine tumor110
Developmental Stage
TissuesTPM*
adult140
embryoid body171
blastocyst146
neonate96
fetus104
infant170
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.9
adrenal gland39.5
appendix33.7
bone marrow25.2
cerebral cortex99.5
colon37.1
duodenum28.4
esophagus48.6
gallbladder50.2
heart muscle26
kidney36.1
liver15
lung42.5
lymph node40.7
ovary55.5
pancreas15.6
placenta50.1
prostate43.4
salivary gland27.1
skin34.5
small intestine30.6
spleen35.6
stomach30.7
testis46.2
thyroid gland68.2
urinary bladder56.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176884, gene) Protein-tyrosine phosphatase, receptor-type, alpha; PTPRAOMIM


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