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> Protein (NX_P18509)
Protein (NX_P18509)
Protein
Gene SymbolADCYAP1 to neXtProt (NX_P18509)
DescriptionPituitary adenylate cyclase-activating polypeptide
Chromosome18
Location18p11.32 (904944 ~ 912173) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of somatostatin secretion
.positive regulation of chemokine (C-C motif) ligand 5 production
.cellular response to glucocorticoid stimulus
  + 38 more...
.peptide hormone receptor binding
.pituitary adenylate cyclase activating polypeptide activity
.neuropeptide hormone activity
  + 2 more...
.terminal bouton
.extracellular space
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 2
2014-09-19protein level
1 23 2
2014-05-27protein level
1 23 2
2014-02-25protein level
1 23 2
2013-12-09protein level
1 19 2
2013-11-01protein level
1 18 2
2013-09-12protein level
1 18 2
2013-08-17protein level
1 18 2
2013-07-15protein level
1 14 2
2013-06-11protein level
1 14 2
2013-02-12protein level
1 4 2
2012-12-20protein level
1 4 2
2012-10-30protein level
1 7 2
2012-10-07protein level
1 7 2
2012-08-24protein level
1 7 2
2012-07-28protein level
1 7 2
2012-06-08protein level
1 13 2
2012-05-07protein level
1 12 2
2012-04-10protein level
1 12 2
2012-01-13protein level
1 9 2
2011-12-20protein level
1 9 2
2011-11-11protein level
1 9 2
2011-08-23protein level
1 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18509-1
10 0 0 18823.6516
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8588930,EBI-1104674 CLU  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood40
brain18
lung11
nerve64
pancreas149
skin9
testis9
uterus4
Health State
TissuesTPM*
normal10
germ cell tumor11
leukemia52
non-neoplasia20
pancreatic tumor114
primitive neuroectodermal tumor of the CNS23
skin tumor7
Developmental Stage
TissuesTPM*
adult11
fetus3
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix12.8
cerebral cortex13.5
colon2.2
esophagus1.3
gallbladder8.1
lymph node1.1
pancreas3.1
testis3.5
urinary bladder2.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*102980, gene) Adenylate cyclase-activating polypeptide 1; ADCYAP1OMIM


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