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> Protein (NX_P18545)
Protein (NX_P18545)
Protein
Gene SymbolPDE6G to neXtProt (NX_P18545)
DescriptionRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Chromosome17
Location17q25.3 (79617489 ~ 79630142) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of G-protein coupled receptor protein signaling pathway
.positive regulation of epidermal growth factor receptor signaling pathway
.negative regulation of catalytic activity
  + 5 more...
.3',5'-cyclic-GMP phosphodiesterase activity
.cGMP binding
.enzyme inhibitor activity
.photoreceptor disc membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 1
2014-09-19protein level
1 13 1
2014-05-27protein level
1 13 1
2014-02-25protein level
1 13 1
2013-12-09protein level
1 10 1
2013-11-01protein level
1 10 1
2013-09-12protein level
1 10 1
2013-08-17protein level
1 10 1
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 2 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18545-1
2 0 0 9637.0004
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2622029,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-2622029,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain2
connective tissue114
eye1077
lung8
muscle65
pancreas4
uterus8
Health State
TissuesTPM*
normal73
chondrosarcoma12
germ cell tumor3
glioma18
retinoblastoma43
soft tissue/muscle tissue tumor127
uterine tumor22
Developmental Stage
TissuesTPM*
adult130
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
appendix5.3
bone marrow5.1
colon1.7
duodenum1.2
gallbladder3.3
kidney1.9
liver2.1
lung2.7
lymph node19.2
placenta10.1
small intestine1.9
spleen25
stomach2.1
testis1.3
urinary bladder2.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*180073, gene) Phosphodiesterase 6g, cgmp-specific, rod, gamma; PDE6GOMIM
2(#613582, phenotype) Retinitis pigmentosa 57; RP57OMIM


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