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> Protein (NX_P18848)
Protein (NX_P18848)
Protein
Gene SymbolATF4 to neXtProt (NX_P18848)
DescriptionCyclic AMP-dependent transcription factor ATF-4
Chromosome22
Location22q13.1 (39915700 ~ 39918691) to Ensembl
Sequene Features : Isoforms 1, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 57 9
2014-09-19protein level
1 41 9
2014-05-27protein level
1 41 9
2014-02-25protein level
1 41 9
2013-12-09protein level
1 31 9
2013-11-01protein level
1 30 8
2013-09-12protein level
1 30 8
2013-08-17protein level
1 30 2
2013-07-15protein level
1 26 1
2013-06-11protein level
1 26 1
2013-02-12protein level
1 19 1
2012-12-20protein level
1 18 1
2012-10-30protein level
1 19 1
2012-10-07protein level
1 19 1
2012-08-24protein level
1 18 1
2012-07-28protein level
1 18 1
2012-06-08protein level
1 22 1
2012-05-07protein level
1 21 1
2012-04-10protein level
1 21 1
2012-01-13protein level
1 12 1
2011-12-20protein level
1 12 1
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P18848-1
10 0 0 38565.1235
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-492498,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-492498,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
3 EBI-492498,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
4 EBI-492498,EBI-740209 CEBPG  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of DNA repair
  + 10 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.transcription factor binding
  + 3 more...
.nucleoplasm
.nucleus
5 EBI-492498,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
6 EBI-492498,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
7 EBI-492498,EBI-713355 GPS2  
  .negative regulation of JNK cascade
.negative regulation of GTPase activity
.JNK cascade
  + 4 more...
.GTPase inhibitor activity
.transcription corepressor activity
.transcriptional repressor complex
.nucleoplasm
8 EBI-492498,EBI-6164177 GOLGA1  
  .protein targeting to Golgi .N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.Golgi cisterna membrane
  + 2 more...
9 EBI-492498,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
10 EBI-492498,EBI-492476 TRIB3  
  .intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.positive regulation of ubiquitin-protein transferase activity
.phosphatidylinositol-mediated signaling
  + 21 more...
.ubiquitin-protein transferase regulator activity
.ubiquitin protein ligase binding
.mitogen-activated protein kinase kinase binding
  + 5 more...
.plasma membrane
.cytosol
.nucleoplasm
.nucleus
11 EBI-492498,EBI-711501 CCDC106  
  .N/A .N/A .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
12 EBI-492498,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
13 EBI-492498,EBI-632965 CREBZF  
  .regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
14 EBI-492498,EBI-9693115 DAPK2  
  .regulation of intrinsic apoptotic signaling pathway
.protein autophosphorylation
.anoikis
  + 5 more...
.identical protein binding
.ATP binding
.calmodulin binding
  + 2 more...
.autophagic vacuole lumen
.cytoplasmic vesicle
.cytoplasm
15 EBI-492498,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue699
adrenal gland333
ascites1330
bladder200
blood744
bone488
bone marrow225
brain226
cervix1237
connective tissue187
ear248
embryonic tissue864
esophagus2332
eye478
heart156
intestine547
kidney398
larynx1960
liver740
lung537
lymph1670
lymph node434
mammary gland489
mouth120
muscle695
nerve643
ovary335
pancreas374
parathyroid291
pharynx245
pituitary gland363
placenta558
prostate532
salivary gland345
skin327
spleen187
stomach585
testis209
thymus138
thyroid257
tonsil293
umbilical cord145
uterus508
vascular600
Health State
TissuesTPM*
normal314
adrenal tumor316
bladder carcinoma113
breast (mammary gland) tumor612
cervical tumor1449
chondrosarcoma289
colorectal tumor702
esophageal tumor2725
gastrointestinal tumor1029
germ cell tumor421
glioma317
head and neck tumor328
kidney tumor377
leukemia793
liver tumor926
lung tumor1099
lymphoma1495
non-neoplasia258
ovarian tumor406
pancreatic tumor380
primitive neuroectodermal tumor of the CNS724
prostate cancer722
retinoblastoma667
skin tumor398
soft tissue/muscle tissue tumor407
uterine tumor732
Developmental Stage
TissuesTPM*
adult479
embryoid body943
blastocyst813
neonate160
fetus258
infant1233
juvenile899
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue215.1
adrenal gland182.9
appendix155.5
bone marrow398.9
cerebral cortex90.2
colon177.4
duodenum153
esophagus166.8
gallbladder219.9
heart muscle124.3
kidney107.4
liver133
lung179.8
lymph node175.8
ovary175.5
pancreas229.1
placenta225.9
prostate169.2
salivary gland281.7
skin133.5
small intestine131.1
spleen114
stomach194
testis93.6
thyroid gland205.4
urinary bladder248.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604064, gene) Activating transcription factor 4; ATF4OMIM


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2014-2019 (C) Yonsei Proteome Research Center