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> Protein (NX_P19012)
Protein (NX_P19012)
Protein
Gene SymbolKRT15 to neXtProt (NX_P19012)
DescriptionKeratin, type I cytoskeletal 15
Chromosome17
Location17q21.2 (39669995 ~ 39678781) to Ensembl
Sequene Features : Isoforms 2, Variants 96, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 96 2
2014-09-19protein level
1 71 2
2014-05-27protein level
1 71 3
2014-02-25protein level
1 70 3
2013-12-09protein level
1 46 3
2013-11-01protein level
1 43 3
2013-09-12protein level
1 43 3
2013-08-17protein level
1 43 3
2013-07-15protein level
1 30 1
2013-06-11protein level
1 30 1
2013-02-12protein level
1 22 0
2012-12-20protein level
1 20 0
2012-10-30protein level
1 21 0
2012-10-07protein level
1 21 0
2012-08-24protein level
1 18 0
2012-07-28protein level
1 18 0
2012-06-08protein level
1 18 0
2012-05-07protein level
1 18 0
2012-04-10protein level
1 18 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19012-1
8 9 8 49180.9373
NX_P19012-2
1 9 5 28584.13
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739566,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-739566,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
3 EBI-739566,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
4 EBI-739566,EBI-9996498 KRT86  
  .N/A .structural molecule activity .extracellular exosome
.keratin filament
.extracellular space
5 EBI-739566,EBI-1049822 TIMM8A  
  .chaperone-mediated protein transport
.cellular protein metabolic process
.nervous system development
.protein targeting to mitochondrion
.metal ion binding .mitochondrial intermembrane space
.mitochondrial inner membrane
.mitochondrion
6 EBI-739566,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
7 EBI-739566,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
8 EBI-739566,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
9 EBI-739566,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
10 EBI-739566,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
11 EBI-739566,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
12 EBI-739566,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
13 EBI-739566,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
14 EBI-739566,EBI-702187 KRT5  
  .cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
.membrane
  + 6 more...
15 EBI-739566,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
16 EBI-739566,EBI-2371606 KRT4  
  .negative regulation of epithelial cell proliferation
.epithelial cell differentiation
.cytoskeleton organization
.structural molecule activity .intermediate filament cytoskeleton
.keratin filament
.cell surface
  + 2 more...
17 EBI-739566,EBI-372273 PSMB1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
18 EBI-739566,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
19 EBI-739566,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
20 EBI-739566,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
21 EBI-739566,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
22 EBI-739566,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
23 EBI-739566,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
24 EBI-739566,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
25 EBI-739566,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
26 EBI-739566,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
27 EBI-739566,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
28 EBI-739566,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
29 EBI-739566,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
30 EBI-739566,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
31 EBI-739566,EBI-2952676 KRT71  
  .intermediate filament organization
.hair follicle morphogenesis
.structural molecule activity .extracellular exosome
.keratin filament
.cytoplasm
32 EBI-739566,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
33 EBI-739566,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
34 EBI-739566,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
35 EBI-739566,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
36 EBI-739566,EBI-2514135 KRT79  
  .N/A .enzyme binding
.structural molecule activity
.extracellular exosome
.keratin filament
37 EBI-739566,EBI-3046635 KRT80  
  .N/A .structural molecule activity .keratin filament
.intermediate filament
.cytoplasm
38 EBI-739566,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
39 EBI-739566,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
40 EBI-739566,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
41 EBI-739566,EBI-2557212 IKBIP  
  .response to X-ray .N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
42 EBI-739566,EBI-741048 NUP54  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.cytoplasm
.nucleoplasm
  + 2 more...
43 EBI-739566,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
44 EBI-739566,EBI-2830994 KRT73  
  .activation of mitophagy in response to mitochondrial depolarization .structural molecule activity .extracellular exosome
.keratin filament
.nucleus
45 EBI-739566,EBI-748515 GLYCTK  
  .protein phosphorylation .glycerate kinase activity
.ATP binding
.mitochondrion
.cytoplasm
46 EBI-739566,EBI-10265323 RIBC1  
  .N/A .N/A .N/A
47 EBI-739566,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
48 EBI-739566,EBI-747505 C1orf216  
  .N/A .N/A .N/A
49 EBI-739566,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
50 EBI-739566,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
51 EBI-739566,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
52 EBI-739566,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
53 EBI-739566,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
54 EBI-739566,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
55 EBI-739566,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
56 EBI-739566,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
57 EBI-739566,EBI-749118 WAC  
  .histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
58 EBI-739566,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
59 EBI-739566,EBI-395927 NOC4L  
  .rRNA processing
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nuclear membrane
.Noc4p-Nop14p complex
  + 3 more...
60 EBI-739566,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
61 EBI-739566,EBI-769270 EPC1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 7 more...
.N/A .NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
.nuclear membrane
  + 2 more...
62 EBI-739566,EBI-3921014 ZNF576  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
63 EBI-739566,EBI-745269 CCNB1IP1  
  .chiasma assembly
.protein ubiquitination
.spermatid development
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.nuclear lumen
.synaptonemal complex
64 EBI-739566,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
65 EBI-739566,EBI-749261 CCDC87  
  .cytokinesis
.microtubule cytoskeleton organization
.N/A .N/A
66 EBI-739566,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
67 EBI-739566,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
68 EBI-739566,EBI-713401 HMG20B  
  .positive regulation of neuron differentiation
.skeletal muscle cell differentiation
.negative regulation of protein sumoylation
  + 6 more...
.chromatin binding
.DNA binding
.chromosome
.nucleoplasm
69 EBI-739566,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
70 EBI-739566,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
71 EBI-739566,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
brain24
embryonic tissue4
esophagus2183
eye52
heart89
intestine17
kidney4
larynx426
liver14
lung131
mammary gland198
mouth393
ovary29
pancreas28
pharynx122
placenta3
prostate126
skin265
stomach20
testis11
thymus50
thyroid21
trachea173
umbilical cord72
Health State
TissuesTPM*
normal40
bladder carcinoma56
breast (mammary gland) tumor42
colorectal tumor26
esophageal tumor2087
gastrointestinal tumor16
glioma242
head and neck tumor261
liver tumor31
lung tumor350
non-neoplasia20
ovarian tumor39
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
prostate cancer86
skin tumor31
Developmental Stage
TissuesTPM*
adult56
neonate32
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
colon2.2
duodenum2.1
esophagus559.1
gallbladder5.1
lung3
prostate84.8
salivary gland33.5
skin687
small intestine2.2
stomach2.8
testis9
urinary bladder12.4
Tissues
TissuesExpression level
breastHigh
bronchusMedium
esophagusHigh
nasopharynxMedium
oral mucosaMedium
prostateMedium
salivary glandLow
skin 1Medium
skin 2Medium
tonsilMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148030, gene) Keratin 15; KRT15OMIM


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