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> Protein (NX_P19013)
Protein (NX_P19013)
Protein
Gene SymbolKRT4 to neXtProt (NX_P19013)
DescriptionKeratin, type II cytoskeletal 4
Chromosome12
Location12q13.13 (53200333 ~ 53208335) to Ensembl
Sequene Features : Isoforms 1, Variants 4, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of epithelial cell proliferation
.epithelial cell differentiation
.cytoskeleton organization
.structural molecule activity .intermediate filament cytoskeleton
.keratin filament
.cell surface
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 4 0
2014-09-19protein level
1 4 0
2014-05-27protein level
1 4 1
2014-02-25protein level
1 4 1
2013-12-09protein level
1 4 1
2013-11-01protein level
1 4 1
2013-09-12protein level
1 4 1
2013-08-17protein level
1 4 1
2013-07-15protein level
1 4 1
2013-06-11protein level
1 4 1
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 4 1
2012-10-07protein level
1 4 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 7 1
2012-05-07protein level
1 7 1
2012-04-10protein level
1 7 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 12 1
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19013-1
21 0 6 57249.6644
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2371606,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-2371606,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-2371606,EBI-1049638 KRT33B  
  .hair cycle
.aging
.structural molecule activity .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-2371606,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
cervix474
esophagus8881
eye90
heart22
larynx1960
liver4
lung20
mammary gland138
mouth8647
muscle18
ovary128
pancreas28
pharynx294
placenta3
prostate36
skin4
thymus12
thyroid42
trachea289
umbilical cord217
uterus12
Health State
TissuesTPM*
normal154
breast (mammary gland) tumor193
esophageal tumor5160
germ cell tumor11
glioma9
head and neck tumor1345
lung tumor19
non-neoplasia93
ovarian tumor170
pancreatic tumor57
prostate cancer38
Developmental Stage
TissuesTPM*
adult59
neonate96
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus6514.6
gallbladder1.3
heart muscle5.1
liver5.4
lung21.1
prostate3.4
urinary bladder3.6
Tissues
TissuesExpression level
bronchusLow
cervix, uterineMedium
colonLow
esophagusHigh
nasopharynxMedium
oral mucosaLow
skin 2Low
tonsilMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123940, gene) Keratin 4; KRT4OMIM
2(#193900, phenotype) White sponge nevus; WSNOMIM


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