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> Protein (NX_P19022)
Protein (NX_P19022)
Protein
Gene SymbolCDH2 to neXtProt (NX_P19022)
DescriptionCadherin-2
Chromosome18
Location18q12.1 (25530930 ~ 25757410) to Ensembl
Sequene Features : Isoforms 2, Variants 225, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neuronal stem cell maintenance
.negative regulation of canonical Wnt signaling pathway
.positive regulation of muscle cell differentiation
  + 14 more...
.gamma-catenin binding
.alpha-catenin binding
.beta-catenin binding
.calcium ion binding
.extracellular exosome
.synapse
.lamellipodium
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 225 8
2014-09-19protein level
1 192 8
2014-05-27protein level
1 192 8
2014-02-25protein level
1 192 8
2013-12-09protein level
1 156 8
2013-11-01protein level
1 148 7
2013-09-12protein level
1 148 7
2013-08-17protein level
1 148 7
2013-07-15protein level
1 103 7
2013-06-11protein level
1 103 7
2013-02-12protein level
1 43 8
2012-12-20protein level
1 43 8
2012-10-30protein level
1 46 8
2012-10-07protein level
1 46 8
2012-08-24protein level
1 19 8
2012-07-28protein level
1 19 8
2012-06-08protein level
1 27 8
2012-05-07protein level
1 27 8
2012-04-10protein level
1 27 8
2012-01-13protein level
1 25 8
2011-12-20protein level
1 25 8
2011-11-11protein level
1 25 8
2011-08-23protein level
1 25 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19022-1
3 31 1 99747.0028
NX_P19022-2
2 31 1 96979.5724
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2256711,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
bone41
bone marrow20
brain76
connective tissue87
embryonic tissue173
eye28
heart111
intestine12
kidney66
liver43
lung5
muscle18
ovary29
pancreas14
prostate21
skin28
testis163
thymus12
thyroid85
vascular232
Health State
TissuesTPM*
normal56
adrenal tumor158
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor8
germ cell tumor64
glioma9
head and neck tumor29
kidney tumor72
liver tumor72
non-neoplasia20
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
prostate cancer28
skin tumor7
soft tissue/muscle tissue tumor71
Developmental Stage
TissuesTPM*
adult36
embryoid body285
blastocyst162
fetus84
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland63.5
appendix2.7
cerebral cortex33.1
colon1.1
duodenum1
gallbladder4
heart muscle147
kidney15
liver33.4
lymph node2
ovary7.4
prostate3.1
small intestine1.5
spleen13.8
stomach4
testis42.3
thyroid gland7.9
urinary bladder2.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
cerebellumLow
cerebral cortexMedium
colonMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeHigh
heart muscleHigh
kidneyHigh
liverHigh
pancreasLow
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114020, gene) Cadherin 2; CDH2OMIM


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