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> Protein (NX_P19174)
Protein (NX_P19174)
Protein
Gene SymbolPLCG1 to neXtProt (NX_P19174)
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Chromosome20
Location20q12 (39765600 ~ 39811629) to Ensembl
Sequene Features : Isoforms 2, Variants 143, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 143 17
2014-09-19protein level
2 105 17
2014-05-27protein level
2 105 17
2014-02-25protein level
2 102 17
2013-12-09protein level
2 82 17
2013-11-01protein level
2 77 15
2013-09-12protein level
2 77 18
2013-08-17protein level
2 77 18
2013-07-15protein level
2 46 14
2013-06-11protein level
2 46 14
2013-02-12protein level
2 25 28
2012-12-20protein level
2 26 28
2012-10-30protein level
2 29 28
2012-10-07protein level
2 29 14
2012-08-24protein level
2 28 14
2012-07-28protein level
2 28 14
2012-06-08protein level
2 28 14
2012-05-07protein level
2 16 14
2012-04-10protein level
2 16 14
2012-01-13protein level
2 8 14
2011-12-20protein level
2 8 14
2011-11-11protein level
2 8 14
2011-08-23protein level
2 8 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19174-1
1 54 0 148437.4583
NX_P19174-2
1 54 0 148565.5165
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-79387,EBI-310968 ASAP2  
  .positive regulation of catalytic activity .zinc ion binding
.enzyme activator activity
.GTPase activator activity
.Golgi cisterna membrane
.plasma membrane
2 EBI-79387,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
3 EBI-79387,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-79387,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-79387,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
6 EBI-79387,EBI-2480756 RET  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.lymphocyte migration into lymphoid organs
.positive regulation of metanephric glomerulus development
  + 30 more...
.ATP binding
.calcium ion binding
.receptor activity
  + 2 more...
.membrane raft
.receptor complex
.intracellular membrane-bounded organelle
  + 4 more...
7 EBI-79387,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
8 EBI-79387,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
9 EBI-79387,EBI-746958 VIL1  
  .positive regulation of lamellipodium morphogenesis
.regulation of lamellipodium morphogenesis
.cellular response to epidermal growth factor stimulus
  + 19 more...
.actin filament binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.protein homodimerization activity
  + 4 more...
.extracellular exosome
.filopodium tip
.actin filament bundle
  + 6 more...
10 EBI-79387,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
11 EBI-79387,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
12 EBI-79387,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
13 EBI-79387,EBI-1028277 FGFR1  
  .regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
.regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
  + 51 more...
.protein homodimerization activity
.identical protein binding
.fibroblast growth factor binding
  + 4 more...
.receptor complex
.cytoplasmic membrane-bounded vesicle
.integral component of membrane
  + 5 more...
14 EBI-79387,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
15 EBI-79387,EBI-78277 CD22  
  .cell adhesion .carbohydrate binding .extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
16 EBI-79387,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
17 EBI-79387,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
18 EBI-79387,EBI-724784 FCGR2B  
  .regulation of immune response
.viral process
.signal transduction
.immune response
.N/A .integral component of membrane
.plasma membrane
19 EBI-79387,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
20 EBI-79387,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
21 EBI-79387,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
22 EBI-79387,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
23 EBI-79387,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
24 EBI-79387,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
25 EBI-79387,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
26 EBI-79387,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
27 EBI-79387,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
28 EBI-79387,EBI-1564650 SCARB2  
  .cell adhesion
.protein targeting to lysosome
.enzyme binding
.receptor activity
.extracellular exosome
.lysosomal lumen
.integral component of membrane
  + 3 more...
29 EBI-79387,EBI-1752620 SNX17  
  .regulation of endocytosis
.endosomal transport
.signal transduction
  + 3 more...
.low-density lipoprotein particle receptor binding
.phosphatidylinositol binding
.protein C-terminus binding
.receptor binding
.protein complex
.intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
  + 8 more...
30 EBI-79387,EBI-1570523 RIN3  
  .positive regulation of GTPase activity
.signal transduction
.endocytosis
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.GTPase activator activity
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
.early endosome
31 EBI-79387,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
32 EBI-79387,EBI-1752330 SHANK3  
  .positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.positive regulation of excitatory postsynaptic membrane potential
.regulation of long term synaptic depression
  + 25 more...
.scaffold protein binding
.identical protein binding
.ionotropic glutamate receptor binding
  + 4 more...
.neuronal postsynaptic density
.ciliary membrane
.postsynaptic membrane
  + 6 more...
33 EBI-79387,EBI-1752795 DUSP15  
  .positive regulation of JNK cascade
.regulation of cell proliferation
.transforming growth factor beta receptor signaling pathway
.protein dephosphorylation
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.plasma membrane
.cytoplasm
34 EBI-79387,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
35 EBI-79387,EBI-1570571 SHANK2  
  .vocalization behavior
.long term synaptic depression
.long-term synaptic potentiation
  + 6 more...
.ionotropic glutamate receptor binding
.GKAP/Homer scaffold activity
.ciliary membrane
.postsynaptic membrane
.dendritic spine
  + 12 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood40
bone27
bone marrow41
brain61
connective tissue20
embryonic tissue140
esophagus49
eye62
heart22
intestine99
kidney33
liver4
lung56
lymph22
lymph node89
mammary gland66
mouth45
muscle65
nerve128
ovary68
pancreas4
pharynx24
placenta31
prostate47
skin52
stomach62
testis36
thymus150
thyroid257
trachea57
uterus60
vascular19
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor96
chondrosarcoma12
colorectal tumor124
esophageal tumor57
gastrointestinal tumor59
germ cell tumor26
glioma83
head and neck tumor59
kidney tumor58
leukemia95
liver tumor10
lung tumor116
lymphoma13
non-neoplasia51
ovarian tumor91
pancreatic tumor9
primitive neuroectodermal tumor of the CNS78
prostate cancer77
retinoblastoma43
skin tumor39
soft tissue/muscle tissue tumor31
uterine tumor77
Developmental Stage
TissuesTPM*
adult70
embryoid body114
blastocyst179
fetus39
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.2
adrenal gland28.1
appendix45.3
bone marrow18
cerebral cortex42.6
colon19.5
duodenum32.2
esophagus25.5
gallbladder45.3
heart muscle35.2
kidney20.3
liver9.4
lung49.1
lymph node81.4
ovary56.3
pancreas8.6
placenta32.1
prostate37.6
salivary gland19.5
skin47.8
small intestine33.5
spleen59.4
stomach21.7
testis46.5
thyroid gland45.7
urinary bladder33.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaLow
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*172420, gene) Phospholipase c, gamma-1; PLCG1OMIM


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