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> Protein (NX_P19338)
Protein (NX_P19338)
Protein
Gene SymbolNCL to neXtProt (NX_P19338)
DescriptionNucleolin
Chromosome2
Location2q37.1 (232318242 ~ 232348352) to Ensembl
Sequene Features : Isoforms 1, Variants 97, PTMs 71 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.angiogenesis
.poly(A) RNA binding
.identical protein binding
.telomeric DNA binding
  + 3 more...
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 97 71
2014-09-19protein level
1 82 71
2014-05-27protein level
1 81 71
2014-02-25protein level
1 82 61
2013-12-09protein level
1 61 61
2013-11-01protein level
1 58 52
2013-09-12protein level
1 58 52
2013-08-17protein level
1 58 52
2013-07-15protein level
1 38 48
2013-06-11protein level
1 38 48
2013-02-12protein level
1 21 41
2012-12-20protein level
1 21 41
2012-10-30protein level
1 22 41
2012-10-07protein level
1 22 41
2012-08-24protein level
1 13 41
2012-07-28protein level
1 12 41
2012-06-08protein level
1 15 41
2012-05-07protein level
1 15 41
2012-04-10protein level
1 15 41
2012-01-13protein level
1 14 41
2011-12-20protein level
1 14 41
2011-11-11protein level
1 14 37
2011-08-23protein level
1 14 37
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19338-1
27 0 0 76568.1433
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346967,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-346967,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
3 EBI-346967,EBI-350338 MYH9  
  .positive regulation of protein processing in phagocytic vesicle
.negative regulation of actin filament severing
.platelet aggregation
  + 24 more...
.actin filament binding
.poly(A) RNA binding
.ADP binding
  + 9 more...
.myosin II filament
.extracellular exosome
.protein complex
  + 18 more...
4 EBI-346967,EBI-2566375 COL18A1  
  .positive regulation of endothelial cell apoptotic process
.response to hydrostatic pressure
.response to drug
  + 11 more...
.metal ion binding
.identical protein binding
.structural molecule activity
.extracellular exosome
.extracellular matrix
.endoplasmic reticulum lumen
  + 4 more...
5 EBI-346967,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
6 EBI-346967,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
7 EBI-346967,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
8 EBI-346967,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-346967,EBI-2683132 PAX8  
  .regulation of thyroid-stimulating hormone secretion
.positive regulation of thyroid hormone generation
.positive regulation of metanephric DCT cell differentiation
  + 30 more...
.transcription regulatory region DNA binding
.thyroid-stimulating hormone receptor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleoplasm
.nucleus
10 EBI-346967,EBI-924893 PA2G4  
  .negative regulation of transcription, DNA-templated
.positive regulation of cell differentiation
.negative regulation of apoptotic process
  + 5 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.extracellular exosome
.ribonucleoprotein complex
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland242
ascites652
bladder301
blood261
bone223
bone marrow246
brain200
cervix144
connective tissue140
ear372
embryonic tissue436
esophagus446
eye158
heart189
intestine504
kidney194
larynx511
liver375
lung149
lymph293
lymph node144
mammary gland416
mouth211
muscle131
nerve257
ovary236
pancreas140
parathyroid242
pharynx49
pituitary gland181
placenta116
prostate242
salivary gland296
skin540
spleen224
stomach167
testis186
thymus288
thyroid300
tonsil293
trachea251
umbilical cord290
uterus206
vascular367
Health State
TissuesTPM*
normal203
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor547
cervical tumor202
chondrosarcoma217
colorectal tumor790
esophageal tumor521
gastrointestinal tumor413
germ cell tumor398
glioma270
head and neck tumor209
kidney tumor145
leukemia296
liver tumor468
lung tumor145
lymphoma221
non-neoplasia103
ovarian tumor262
pancreatic tumor142
primitive neuroectodermal tumor of the CNS370
prostate cancer337
retinoblastoma258
skin tumor295
soft tissue/muscle tissue tumor191
uterine tumor110
Developmental Stage
TissuesTPM*
adult278
embryoid body400
blastocyst585
neonate579
fetus244
infant212
juvenile449
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue231.5
adrenal gland234.8
appendix289.8
bone marrow278.9
cerebral cortex171
colon221.4
duodenum178.2
esophagus204.2
gallbladder171.3
heart muscle147.4
kidney167.9
liver125.7
lung157.5
lymph node308.4
ovary306.8
pancreas127.4
placenta226
prostate164.6
salivary gland132.5
skin165.1
small intestine180.9
spleen186.6
stomach168.3
testis177.8
thyroid gland208.9
urinary bladder209.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164035, gene) Nucleolin; NCLOMIM


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