Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P19438)
Protein (NX_P19438)
Protein
Gene SymbolTNFRSF1A to neXtProt (NX_P19438)
DescriptionTumor necrosis factor receptor superfamily member 1A
Chromosome12
Location12p13.31 (6437923 ~ 6451280) to Ensembl
Sequene Features : Isoforms 5, Variants 84, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.death-inducing signaling complex assembly
.cellular response to estradiol stimulus
.cellular response to mechanical stimulus
  + 29 more...
.tumor necrosis factor-activated receptor activity .synapse
.membrane raft
.receptor complex
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 84 15
2014-09-19protein level
5 71 15
2014-05-27protein level
5 71 15
2014-02-25protein level
5 71 15
2013-12-09protein level
5 66 15
2013-11-01protein level
5 65 15
2013-09-12protein level
5 65 15
2013-08-17protein level
5 65 15
2013-07-15protein level
4 64 15
2013-06-11protein level
4 64 15
2013-02-12protein level
4 56 36
2012-12-20protein level
3 34 23
2012-10-30protein level
3 38 23
2012-10-07protein level
3 38 15
2012-08-24protein level
3 34 15
2012-07-28protein level
3 33 15
2012-06-08protein level
3 39 15
2012-05-07protein level
3 39 15
2012-04-10protein level
3 39 15
2012-01-13protein level
3 70 15
2011-12-20protein level
3 70 15
2011-11-11protein level
3 70 15
2011-08-23protein level
3 70 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P19438-1
0 19 0 50461.7065
NX_P19438-2
1 13 0 38626.0269
NX_P19438-3
0 8 0 24778.4896
NX_P19438-4
1 9 0 25560.0366
NX_P19438-5
2 9 0 24177.532
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-299451,EBI-359977 TNF  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of chemokine (C-X-C motif) ligand 2 production
.positive regulation of protein localization to cell surface
  + 113 more...
.transcription regulatory region DNA binding
.identical protein binding
.tumor necrosis factor receptor binding
  + 2 more...
.recycling endosome
.membrane raft
.cell surface
  + 6 more...
2 EBI-299451,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
3 EBI-299451,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-299451,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
5 EBI-299451,EBI-359215 TRADD  
  .regulation of extrinsic apoptotic signaling pathway via death domain receptors
.programmed necrotic cell death
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  + 17 more...
.death domain binding
.binding, bridging
.identical protein binding
  + 2 more...
.membrane raft
.receptor complex
.death-inducing signaling complex
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland789
ascites200
bladder401
blood556
bone153
bone marrow164
brain254
cervix268
connective tissue657
embryonic tissue89
esophagus645
eye47
heart156
intestine357
kidney294
larynx85
liver165
lung256
mammary gland231
mouth332
muscle75
nerve514
ovary78
pancreas32
parathyroid48
pharynx24
placenta204
prostate226
skin241
spleen1142
stomach271
testis140
thymus715
thyroid85
trachea540
umbilical cord145
uterus400
vascular716
Health State
TissuesTPM*
normal250
breast (mammary gland) tumor333
cervical tumor289
chondrosarcoma132
colorectal tumor44
esophageal tumor579
gastrointestinal tumor185
germ cell tumor642
glioma904
head and neck tumor74
kidney tumor87
leukemia148
liver tumor312
lung tumor136
lymphoma69
non-neoplasia703
ovarian tumor91
pancreatic tumor66
primitive neuroectodermal tumor of the CNS307
prostate cancer96
skin tumor71
soft tissue/muscle tissue tumor71
uterine tumor122
Developmental Stage
TissuesTPM*
adult227
embryoid body114
blastocyst65
neonate1062
fetus70
infant42
juvenile701
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue114.2
adrenal gland102.5
appendix96
bone marrow39.6
cerebral cortex27.6
colon69.6
duodenum108.3
esophagus77.9
gallbladder118.2
heart muscle34.6
kidney40.9
liver86.6
lung86.7
lymph node48.2
ovary56.5
pancreas23.5
placenta93.7
prostate44.1
salivary gland37.7
skin69.4
small intestine118.8
spleen70.5
stomach56
testis28.3
thyroid gland49.6
urinary bladder106.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#142680, phenotype) Periodic fever, familial, autosomal dominantOMIM
2(*191190, gene) Tumor necrosis factor receptor superfamily, member 1a; TNFRSF1AOMIM
3(#614810, phenotype) Multiple sclerosis, susceptibility to, 5; MS5OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center