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> Protein (NX_P20138)
Protein (NX_P20138)
Protein
Gene SymbolCD33 to neXtProt (NX_P20138)
DescriptionMyeloid cell surface antigen CD33
Chromosome19
Location19q13.41 (51728320 ~ 51747115) to Ensembl
Sequene Features : Isoforms 3, Variants 106, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell proliferation
.cell-cell signaling
.signal transduction
.cell adhesion
.carbohydrate binding
.receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 106 10
2014-09-19protein level
3 77 10
2014-05-27protein level
3 77 10
2014-02-25protein level
3 77 10
2013-12-09protein level
3 66 10
2013-11-01protein level
3 63 10
2013-09-12protein level
3 63 10
2013-08-17protein level
3 63 10
2013-07-15protein level
3 48 10
2013-06-11protein level
3 48 10
2013-02-12protein level
2 30 18
2012-12-20protein level
1 30 10
2012-10-30protein level
1 31 10
2012-10-07protein level
1 31 10
2012-08-24protein level
1 31 10
2012-07-28protein level
1 31 10
2012-06-08protein level
1 33 10
2012-05-07protein level
1 30 10
2012-04-10protein level
1 30 10
2012-01-13protein level
1 21 10
2011-12-20protein level
1 21 10
2011-11-11protein level
1 21 10
2011-08-23protein level
1 21 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20138-1
0 16 0 39799.9758
NX_P20138-2
1 13 0 33868.2869
NX_P20138-3
1 9 0 25276.8733
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3906571,EBI-78260 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
2 EBI-3906571,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
3 EBI-3906571,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-3906571,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone41
bone marrow41
brain3
connective tissue6
kidney14
liver14
lung5
lymph node11
parathyroid48
placenta10
prostate5
testis2
thymus12
trachea19
uterus8
Health State
TissuesTPM*
normal7
chondrosarcoma36
glioma18
leukemia63
lymphoma13
prostate cancer9
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland5.2
appendix15.8
bone marrow25.4
cerebral cortex2.5
colon5.1
duodenum5.2
esophagus2.6
gallbladder9
heart muscle2.2
kidney1.8
liver3.1
lung11.3
lymph node11.6
ovary1.6
placenta8.3
prostate1.4
salivary gland1.9
skin3.7
small intestine5.5
spleen28.8
stomach3.5
testis2.2
thyroid gland1.1
urinary bladder7.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*159590, gene) Cd33 antigen; CD33OMIM


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