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> Protein (NX_P20226)
Protein (NX_P20226)
Protein
Gene SymbolTBP to neXtProt (NX_P20226)
DescriptionTATA-box-binding protein
Chromosome6
Location6q27 (170863390 ~ 170881958) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 12 more...
.repressing transcription factor binding
.transcription regulatory region DNA binding
.enzyme binding
  + 2 more...
.cytoplasm
.nuclear euchromatin
.transcription factor TFIIA complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 3
2014-09-19protein level
2 21 3
2014-05-27protein level
2 21 3
2014-02-25protein level
2 21 3
2013-12-09protein level
2 18 3
2013-11-01protein level
2 17 0
2013-09-12protein level
2 17 0
2013-08-17protein level
2 17 0
2013-07-15protein level
2 11 0
2013-06-11protein level
2 11 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 8 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20226-1
1 3 3 37674.3557
NX_P20226-2
1 3 3 35634.4242
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355371,EBI-781310 EDF1  
  .positive regulation of transcription, DNA-templated
.endothelial cell differentiation
.positive regulation of DNA binding
  + 4 more...
.poly(A) RNA binding
.sequence-specific DNA binding
.transcription coactivator activity
.extracellular exosome
.cytoplasm
.nucleolus
  + 2 more...
2 EBI-355371,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-355371,EBI-1167176 POU3F2  
  .cellular response to organic substance
.regulation of axonogenesis
.positive regulation of multicellular organism growth
  + 9 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription coactivator activity
.transcription factor complex
.nucleus
4 EBI-355371,EBI-491289 TAF1  
  .positive regulation of transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcriptional preinitiation complex assembly
.protein autophosphorylation
  + 13 more...
.lysine-acetylated histone binding
.sequence-specific DNA binding
.TBP-class protein binding
  + 6 more...
.MLL1 complex
.transcription factor TFIID complex
.nucleoplasm
5 EBI-355371,EBI-1045262 GTF2A2  
  .RNA polymerase II transcriptional preinitiation complex assembly
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.protein heterodimerization activity
.protein homodimerization activity
.TBP-class protein binding
  + 2 more...
.cell junction
.transcription factor TFIIA complex
.nucleoplasm
6 EBI-355371,EBI-1053182 SET  
  .negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
7 EBI-355371,EBI-2510659 TAF1C  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 6 more...
.DNA binding .nucleoplasm
8 EBI-355371,EBI-1034238 TAF12  
  .regulation of nucleic acid-templated transcription
.positive regulation of sequence-specific DNA binding transcription factor activity
.histone H3 acetylation
  + 7 more...
.transcription factor binding
.transcription coactivator activity
.DNA binding
.transcription factor TFTC complex
.STAGA complex
.transcription factor TFIID complex
  + 2 more...
9 EBI-355371,EBI-1560239 TAF1B  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 7 more...
.metal ion binding
.TBP-class protein binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.RNA polymerase I core factor complex
.extracellular exosome
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood24
bone41
brain35
cervix20
connective tissue33
embryonic tissue51
eye28
heart11
intestine38
kidney33
larynx85
lung29
lymph node55
mammary gland26
muscle47
nerve64
ovary9
pancreas23
parathyroid48
pharynx49
pituitary gland121
placenta38
prostate5
skin18
spleen37
stomach114
testis68
thymus62
uterus38
vascular38
Health State
TissuesTPM*
normal38
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor84
germ cell tumor34
glioma55
head and neck tumor22
kidney tumor43
leukemia52
lung tumor9
lymphoma13
non-neoplasia31
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult32
embryoid body14
blastocyst81
fetus32
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.9
adrenal gland8
appendix10.4
bone marrow8.8
cerebral cortex7.9
colon7.9
duodenum8.1
esophagus8.2
gallbladder9.3
heart muscle6.8
kidney7.5
liver3.9
lung9.3
lymph node13.9
ovary11.3
pancreas4.2
placenta11.3
prostate8.1
salivary gland7.7
skin10.3
small intestine8.3
spleen10.6
stomach7.9
testis31.1
thyroid gland9.9
urinary bladder9.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600075, gene) Tata box-binding protein; TBPOMIM
2(#607136, phenotype) Spinocerebellar ataxia 17; SCA17OMIM


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