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> Protein (NX_P20333)
Protein (NX_P20333)
Protein
Gene SymbolTNFRSF1B to neXtProt (NX_P20333)
DescriptionTumor necrosis factor receptor superfamily member 1B
Chromosome1
Location1p36.22 (12227060 ~ 12269285) to Ensembl
Sequene Features : Isoforms 2, Variants 51, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to lipopolysaccharide
  + 8 more...
.ubiquitin protein ligase binding
.tumor necrosis factor-activated receptor activity
.perinuclear region of cytoplasm
.membrane raft
.varicosity
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 51 15
2014-09-19protein level
2 41 15
2014-05-27protein level
2 41 15
2014-02-25protein level
2 41 15
2013-12-09protein level
2 29 15
2013-11-01protein level
2 27 15
2013-09-12protein level
2 27 15
2013-08-17protein level
2 27 15
2013-07-15protein level
2 20 12
2013-06-11protein level
2 20 12
2013-02-12protein level
2 13 24
2012-12-20protein level
2 13 24
2012-10-30protein level
2 16 24
2012-10-07protein level
2 16 12
2012-08-24protein level
2 16 12
2012-07-28protein level
2 16 12
2012-06-08protein level
2 13 12
2012-05-07protein level
2 13 12
2012-04-10protein level
2 13 12
2012-01-13protein level
2 13 12
2011-12-20protein level
2 14 12
2011-11-11protein level
2 14 12
2011-08-23protein level
2 14 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20333-1
7 8 0 48259.8828
NX_P20333-2
1 8 0 28442.1769
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358983,EBI-359977 TNF  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of chemokine (C-X-C motif) ligand 2 production
.positive regulation of protein localization to cell surface
  + 113 more...
.transcription regulatory region DNA binding
.identical protein binding
.tumor necrosis factor receptor binding
  + 2 more...
.recycling endosome
.membrane raft
.cell surface
  + 6 more...
2 EBI-358983,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
3 EBI-358983,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood73
bone27
brain6
connective tissue33
eye9
heart22
intestine64
kidney33
lung50
lymph node33
mammary gland39
muscle65
nerve64
ovary9
pancreas107
pharynx24
pituitary gland60
placenta31
prostate21
skin4
spleen149
stomach62
testis4
thymus12
uterus25
vascular38
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor21
chondrosarcoma48
colorectal tumor79
gastrointestinal tumor33
germ cell tumor22
glioma37
leukemia31
lung tumor19
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor123
primitive neuroectodermal tumor of the CNS7
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult43
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.6
adrenal gland10.9
appendix79.3
bone marrow43.7
cerebral cortex7.3
colon16.8
duodenum17.3
esophagus9.4
gallbladder28.1
heart muscle9
kidney5.4
liver14.3
lung28
lymph node49.6
ovary6.1
pancreas3.2
placenta38.3
prostate5.9
salivary gland5.5
skin5.5
small intestine22.9
spleen66.8
stomach17.7
testis4.4
thyroid gland4.6
urinary bladder32.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191191, gene) Tumor necrosis factor receptor subfamily, member 1b; TNFRSF1BOMIM


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