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> Protein (NX_P20339)
Protein (NX_P20339)
Protein
Gene SymbolRAB5A to neXtProt (NX_P20339)
DescriptionRas-related protein Rab-5A
Chromosome3
Location3p24.3 (19988571 ~ 20026667) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of synaptic vesicle exocytosis
.receptor internalization involved in canonical Wnt signaling pathway
.regulation of filopodium assembly
  + 12 more...
.GDP binding
.GTP binding
.GTPase activity
.cytoplasmic side of early endosome membrane
.extracellular exosome
.recycling endosome
  + 22 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 3
2014-09-19protein level
2 23 3
2014-05-27protein level
1 23 4
2014-02-25protein level
1 23 4
2013-12-09protein level
1 19 4
2013-11-01protein level
1 19 4
2013-09-12protein level
1 19 4
2013-08-17protein level
1 19 4
2013-07-15protein level
1 9 3
2013-06-11protein level
1 9 3
2013-02-12protein level
1 4 7
2012-12-20protein level
1 4 7
2012-10-30protein level
1 5 7
2012-10-07protein level
1 5 7
2012-08-24protein level
1 5 7
2012-07-28protein level
1 5 7
2012-06-08protein level
1 16 7
2012-05-07protein level
1 16 7
2012-04-10protein level
1 16 7
2012-01-13protein level
1 14 7
2011-12-20protein level
1 14 7
2011-11-11protein level
1 14 7
2011-08-23protein level
1 14 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20339-1
1 7 3 23643.7504
NX_P20339-2
1 7 3 22164.0628
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-399437,EBI-6148898 OCRL  
  .regulation of small GTPase mediated signal transduction
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 9 more...
.inositol phosphate phosphatase activity
.Rac GTPase binding
.GTPase activator activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.extracellular exosome
.early endosome membrane
.phagocytic vesicle membrane
  + 11 more...
2 EBI-399437,EBI-298113 EEA1  
  .early endosome to late endosome transport
.synaptic vesicle to endosome fusion
.vesicle fusion
.endocytosis
.protein homodimerization activity
.GTP-dependent protein binding
.zinc ion binding
  + 2 more...
.extracellular exosome
.recycling endosome
.axonal spine
  + 8 more...
3 EBI-399437,EBI-1044902 ALS2  
  .positive regulation of protein serine/threonine kinase activity
.regulation of endosome size
.neuron projection morphogenesis
  + 13 more...
.protein serine/threonine kinase activator activity
.protein homodimerization activity
.Rac guanyl-nucleotide exchange factor activity
  + 3 more...
.protein complex
.dendritic spine
.vesicle
  + 8 more...
4 EBI-399437,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland182
ascites25
bladder167
blood65
bone27
bone marrow123
brain126
cervix61
connective tissue40
ear62
embryonic tissue79
esophagus49
eye33
heart134
intestine51
kidney151
larynx42
liver82
lung71
lymph22
lymph node22
mammary gland59
mouth120
muscle47
nerve128
ovary98
pancreas65
parathyroid145
pharynx147
placenta130
prostate79
salivary gland98
skin71
spleen74
stomach20
testis80
thymus100
thyroid42
tonsil58
trachea57
uterus103
vascular290
Health State
TissuesTPM*
normal95
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma24
colorectal tumor71
esophageal tumor57
gastrointestinal tumor25
germ cell tumor98
glioma111
head and neck tumor89
kidney tumor130
leukemia31
liver tumor93
lung tumor38
lymphoma41
non-neoplasia93
ovarian tumor118
pancreatic tumor85
primitive neuroectodermal tumor of the CNS62
prostate cancer96
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult74
embryoid body100
blastocyst65
neonate289
fetus91
infant85
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.8
adrenal gland32.1
appendix34.7
bone marrow41
cerebral cortex49.5
colon33.7
duodenum30.9
esophagus51
gallbladder43.4
heart muscle34.1
kidney31.2
liver23.8
lung33.2
lymph node29.2
ovary24.5
pancreas15.8
placenta51.4
prostate32.3
salivary gland27.4
skin34.8
small intestine30.2
spleen25.2
stomach32.9
testis24
thyroid gland51.4
urinary bladder42.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*179512, gene) Ras-associated protein rab5a; RAB5AOMIM


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