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> Protein (NX_P20591)
Protein (NX_P20591)
Protein
Gene SymbolMX1 to neXtProt (NX_P20591)
DescriptionInterferon-induced GTP-binding protein Mx1
Chromosome21
Location21q22.3 (42792231 ~ 42831141) to Ensembl
Sequene Features : Isoforms 2, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.type I interferon signaling pathway
.defense response to virus
.innate immune response
  + 7 more...
.GTP binding
.GTPase activity
.perinuclear region of cytoplasm
.nuclear membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 86 1
2014-09-19protein level
2 65 1
2014-05-27protein level
2 65 1
2014-02-25protein level
2 66 1
2013-12-09protein level
2 48 1
2013-11-01protein level
2 45 1
2013-09-12protein level
2 45 1
2013-08-17protein level
2 45 1
2013-07-15protein level
2 32 1
2013-06-11protein level
2 32 1
2013-02-12protein level
2 22 5
2012-12-20protein level
2 22 5
2012-10-30protein level
2 25 5
2012-10-07protein level
2 25 3
2012-08-24protein level
2 24 3
2012-07-28protein level
2 24 3
2012-06-08protein level
2 19 3
2012-05-07protein level
2 19 3
2012-04-10protein level
2 19 3
2012-01-13protein level
1 13 3
2011-12-20protein level
1 13 3
2011-11-11protein level
1 13 3
2011-08-23protein level
1 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20591-1
10 16 3 75473.0006
NX_P20591-2
3 16 3 55626.4724
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-929476,EBI-520807 TRPC3  
  .positive regulation of cardiac muscle hypertrophy in response to stress
.calcium ion transmembrane transport
.transmembrane transport
  + 10 more...
.inositol 1,4,5 trisphosphate binding
.store-operated calcium channel activity
.calcium channel activity
.integral component of plasma membrane
.plasma membrane
2 EBI-929476,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
3 EBI-929476,EBI-1047244 CAB39L  
  .insulin receptor signaling pathway
.cell cycle arrest
.N/A .extracellular exosome
.cytosol
4 EBI-929476,EBI-929504 TRPC4  
  .calcium ion transmembrane transport
.calcium ion import
.transmembrane transport
  + 7 more...
.inositol 1,4,5 trisphosphate binding
.cadherin binding
.store-operated calcium channel activity
.beta-catenin binding
.calcium channel complex
.cortical cytoskeleton
.basolateral plasma membrane
  + 4 more...
5 EBI-929476,EBI-929362 TRPC6  
  .cellular response to hypoxia
.calcium ion transmembrane transport
.cellular response to hydrogen peroxide
  + 12 more...
.inositol 1,4,5 trisphosphate binding
.store-operated calcium channel activity
.slit diaphragm
.membrane
.integral component of plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder435
blood114
bone55
brain47
cervix144
connective tissue87
esophagus148
eye43
heart44
intestine99
kidney37
larynx85
liver34
lung98
lymph node167
mammary gland119
mouth181
muscle47
nerve128
ovary177
pancreas60
parathyroid48
pharynx171
pituitary gland60
placenta38
prostate36
salivary gland49
skin61
spleen449
stomach41
testis43
thymus213
thyroid21
tonsil235
trachea57
uterus176
vascular116
Health State
TissuesTPM*
normal76
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor202
chondrosarcoma72
colorectal tumor133
esophageal tumor173
gastrointestinal tumor42
germ cell tumor136
glioma65
head and neck tumor127
kidney tumor29
leukemia63
liver tumor52
lung tumor38
lymphoma83
non-neoplasia31
ovarian tumor236
pancreatic tumor76
skin tumor15
soft tissue/muscle tissue tumor159
uterine tumor133
Developmental Stage
TissuesTPM*
adult100
fetus57
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.6
adrenal gland18.3
appendix35.2
bone marrow38.2
cerebral cortex16.4
colon24.1
duodenum33.5
esophagus38.8
gallbladder50.6
heart muscle13.9
kidney14
liver12.8
lung37.2
lymph node44.5
ovary29.7
pancreas7.8
placenta19.1
prostate12.5
salivary gland95.1
skin6.3
small intestine29.3
spleen92.3
stomach36.7
testis14.7
thyroid gland28.7
urinary bladder42.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147150, gene) Myxovirus resistance 1, mouse, homolog of; MX1OMIM


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