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> Protein (NX_P20592)
Protein (NX_P20592)
Protein
Gene SymbolMX2 to neXtProt (NX_P20592)
DescriptionInterferon-induced GTP-binding protein Mx2
Chromosome21
Location21q22.3 (42733870 ~ 42781317) to Ensembl
Sequene Features : Isoforms 2, Variants 88, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.type I interferon signaling pathway
.regulation of cell cycle
.defense response to virus
  + 8 more...
.GTP binding
.GTPase activity
.cytosol
.cytoplasm
.nuclear pore
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 88 0
2014-09-19protein level
1 72 0
2014-05-27protein level
1 72 0
2014-02-25protein level
1 72 0
2013-12-09protein level
1 56 0
2013-11-01protein level
1 55 0
2013-09-12protein level
1 55 0
2013-08-17protein level
1 55 0
2013-07-15protein level
1 38 0
2013-06-11protein level
1 38 0
2013-02-12protein level
1 18 1
2012-12-20protein level
1 18 1
2012-10-30protein level
1 22 1
2012-10-07protein level
1 22 1
2012-08-24protein level
1 21 1
2012-07-28protein level
1 21 1
2012-06-08protein level
1 22 1
2012-05-07protein level
1 14 1
2012-04-10protein level
1 14 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20592-1
29 6 3 82036.4515
NX_P20592-2
1 6 3 22091.25
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10200618,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
2 EBI-10200618,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder133
blood73
bone27
brain9
connective tissue33
embryonic tissue4
eye23
heart44
intestine25
larynx85
liver4
lung17
lymph node144
mammary gland26
mouth15
pancreas14
pharynx73
placenta17
prostate5
skin18
spleen187
stomach31
testis48
thymus250
trachea38
uterus51
vascular19
Health State
TissuesTPM*
normal24
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor42
germ cell tumor56
glioma9
head and neck tumor37
leukemia21
liver tumor10
lung tumor9
lymphoma13
non-neoplasia10
pancreatic tumor28
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult33
embryoid body14
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.8
adrenal gland3.9
appendix33.9
bone marrow18.6
cerebral cortex3.4
colon8.9
duodenum10.8
esophagus8.7
gallbladder26.3
heart muscle6.2
kidney3.9
liver2.8
lung14.1
lymph node26.4
ovary7.4
pancreas2.7
placenta7.7
prostate3
salivary gland8.4
skin4.8
small intestine12.1
spleen44.3
stomach24.2
testis6.8
thyroid gland3.4
urinary bladder26.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147890, gene) Myxovirus resistance 2, mouse, homolog of; MX2OMIM


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