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> Protein (NX_P20618)
Protein (NX_P20618)
Protein
Gene SymbolPSMB1 to neXtProt (NX_P20618)
DescriptionProteasome subunit beta type-1
Chromosome6
Location6q27 (170844205 ~ 170862429) to Ensembl
Sequene Features : Isoforms 1, Variants 21, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 21 10
2014-09-19protein level
1 16 10
2014-05-27protein level
1 16 10
2014-02-25protein level
1 16 10
2013-12-09protein level
1 11 10
2013-11-01protein level
1 11 10
2013-09-12protein level
1 11 10
2013-08-17protein level
1 11 10
2013-07-15protein level
1 6 4
2013-06-11protein level
1 6 4
2013-02-12protein level
1 5 4
2012-12-20protein level
1 4 4
2012-10-30protein level
1 7 4
2012-10-07protein level
1 7 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 6 2
2011-12-20protein level
1 6 2
2011-11-11protein level
1 6 2
2011-08-23protein level
1 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20618-1
13 0 0 26472.2948
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-372273,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-372273,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-372273,EBI-357828 PSMB5  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 5 more...
4 EBI-372273,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-372273,EBI-603319 PSMB7  
  .positive regulation of protein targeting to mitochondrion
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
6 EBI-372273,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
7 EBI-372273,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland303
ascites200
bladder100
blood278
bone55
bone marrow246
brain80
cervix61
connective tissue80
ear310
embryonic tissue164
esophagus148
eye134
heart212
intestine193
kidney222
liver209
lung232
lymph406
lymph node77
mammary gland165
mouth30
muscle75
nerve64
ovary295
pancreas149
parathyroid97
pharynx441
pituitary gland181
placenta176
prostate189
salivary gland493
skin161
spleen56
stomach177
testis119
thymus75
thyroid107
tonsil117
trachea38
umbilical cord435
uterus146
vascular96
Health State
TissuesTPM*
normal126
adrenal tumor316
bladder carcinoma454
breast (mammary gland) tumor96
cervical tumor86
chondrosarcoma132
colorectal tumor248
esophageal tumor173
gastrointestinal tumor160
germ cell tumor258
glioma158
head and neck tumor82
kidney tumor174
leukemia158
liver tumor260
lung tumor389
lymphoma290
non-neoplasia103
ovarian tumor196
pancreatic tumor161
primitive neuroectodermal tumor of the CNS165
prostate cancer173
retinoblastoma150
skin tumor199
soft tissue/muscle tissue tumor71
uterine tumor166
Developmental Stage
TissuesTPM*
adult134
embryoid body142
blastocyst65
neonate193
fetus93
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue119.2
adrenal gland134.8
appendix131.1
bone marrow117.4
cerebral cortex74.4
colon138.7
duodenum123
esophagus134.3
gallbladder119.2
heart muscle149.3
kidney125.5
liver123.4
lung110
lymph node155.1
ovary107.9
pancreas52
placenta159.3
prostate112.4
salivary gland86.9
skin112.2
small intestine122
spleen100
stomach100.1
testis89.7
thyroid gland130.1
urinary bladder138
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602017, gene) Proteasome subunit, beta-type, 1; PSMB1OMIM


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