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> Protein (NX_P20674)
Protein (NX_P20674)
Protein
Gene SymbolCOX5A to neXtProt (NX_P20674)
DescriptionCytochrome c oxidase subunit 5A, mitochondrial
Chromosome15
Location15q24.2 (75212132 ~ 75230509) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.metal ion binding
.electron carrier activity
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 3
2014-09-19protein level
1 16 3
2014-05-27protein level
1 16 3
2014-02-25protein level
1 16 3
2013-12-09protein level
1 12 3
2013-11-01protein level
1 12 2
2013-09-12protein level
1 12 0
2013-08-17protein level
1 12 0
2013-07-15protein level
1 6 0
2013-06-11protein level
1 6 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20674-1
7 0 0 16751.6406
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715032,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
2 EBI-715032,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
3 EBI-715032,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone55
bone marrow41
brain58
cervix20
connective tissue107
ear124
embryonic tissue56
eye86
heart89
intestine163
kidney75
liver38
lung53
lymph22
lymph node178
mammary gland105
mouth15
muscle178
nerve64
ovary49
pancreas126
parathyroid145
pharynx24
placenta60
prostate52
salivary gland98
skin47
spleen37
stomach125
testis45
thyroid150
trachea19
umbilical cord72
uterus81
Health State
TissuesTPM*
normal67
bladder carcinoma56
breast (mammary gland) tumor150
cervical tumor28
chondrosarcoma48
colorectal tumor133
gastrointestinal tumor59
germ cell tumor53
glioma177
head and neck tumor74
kidney tumor14
leukemia63
liver tumor41
lung tumor38
lymphoma27
non-neoplasia20
ovarian tumor39
pancreatic tumor28
prostate cancer86
retinoblastoma215
skin tumor39
soft tissue/muscle tissue tumor167
uterine tumor11
Developmental Stage
TissuesTPM*
adult91
embryoid body71
blastocyst48
neonate32
fetus55
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue113.6
adrenal gland96
appendix98.5
bone marrow83.3
cerebral cortex105.9
colon338.9
duodenum245.8
esophagus133.3
gallbladder72.2
heart muscle521.2
kidney186.2
liver135
lung67.6
lymph node112.3
ovary38.1
pancreas64.7
placenta77.7
prostate92.5
salivary gland122.8
skin54.2
small intestine215.3
spleen73.9
stomach153.8
testis117.9
thyroid gland95.8
urinary bladder119.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603773, gene) Cytochrome c oxidase, subunit va; COX5AOMIM


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