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> Protein (NX_P20813)
Protein (NX_P20813)
Protein
Gene SymbolCYP2B6 to neXtProt (NX_P20813)
DescriptionCytochrome P450 2B6
Chromosome19
Location19q13.2 (41497204 ~ 41524303) to Ensembl
Sequene Features : Isoforms 2, Variants 139, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.oxidation-reduction process
.small molecule metabolic process
.exogenous drug catabolic process
  + 5 more...
.heme binding
.oxygen binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
  + 4 more...
.intracellular membrane-bounded organelle
.endoplasmic reticulum membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 139 1
2014-09-19protein level
2 110 1
2014-05-27protein level
1 109 1
2014-02-25protein level
1 106 1
2013-12-09protein level
1 94 1
2013-11-01protein level
1 91 1
2013-09-12protein level
1 91 1
2013-08-17protein level
1 91 1
2013-07-15protein level
1 71 1
2013-06-11protein level
1 71 1
2013-02-12protein level
1 48 1
2012-12-20protein level
1 48 1
2012-10-30protein level
1 52 1
2012-10-07protein level
1 52 1
2012-08-24protein level
1 51 1
2012-07-28protein level
1 51 1
2012-06-08protein level
1 54 1
2012-05-07protein level
1 52 1
2012-04-10protein level
1 52 1
2012-01-13protein level
1 36 1
2011-12-20protein level
1 36 1
2011-11-11protein level
1 36 1
2011-08-23protein level
1 36 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20813-1
10 12 0 56242.1732
NX_P20813-2
1 12 0 33362.9086
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
intestine17
kidney14
liver58
mammary gland26
muscle9
Health State
TissuesTPM*
normal5
colorectal tumor35
liver tumor20
Developmental Stage
TissuesTPM*
adult8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
colon5.4
duodenum5.8
gallbladder1.5
kidney14.4
liver410.6
lung1.3
small intestine8.1
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusLow
cerebellumLow
cerebral cortexLow
colonLow
duodenumLow
endometrium 1Low
esophagusLow
fallopian tubeLow
gallbladderLow
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleLow
liverHigh
lungLow
lymph nodeLow
nasopharynxLow
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
small intestineLow
soft tissue 1Low
stomach 1Low
stomach 2Low
testisLow
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123930, gene) Cytochrome p450, subfamily iib, polypeptide 6; CYP2B6OMIM
2(#614546, phenotype) Efavirenz, poor metabolism ofOMIM


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