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> Protein (NX_P20936)
Protein (NX_P20936)
Protein
Gene SymbolRASA1 to neXtProt (NX_P20936)
DescriptionRas GTPase-activating protein 1
Chromosome5
Location5q14.3 (86563705 ~ 86687748) to Ensembl
Sequene Features : Isoforms 2, Variants 117, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 117 2
2014-09-19protein level
2 92 2
2014-05-27protein level
2 92 2
2014-02-25protein level
2 92 2
2013-12-09protein level
2 76 2
2013-11-01protein level
2 74 2
2013-09-12protein level
2 74 1
2013-08-17protein level
2 74 1
2013-07-15protein level
2 45 1
2013-06-11protein level
2 45 1
2013-02-12protein level
2 26 2
2012-12-20protein level
2 26 2
2012-10-30protein level
2 34 2
2012-10-07protein level
2 34 1
2012-08-24protein level
2 30 1
2012-07-28protein level
2 30 1
2012-06-08protein level
2 33 1
2012-05-07protein level
2 21 1
2012-04-10protein level
2 21 1
2012-01-13protein level
2 10 1
2011-12-20protein level
2 10 1
2011-11-11protein level
2 10 1
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20936-1
3 45 0 116329.1282
NX_P20936-2
0 45 0 100334.1749
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1026476,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1026476,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-1026476,EBI-711828 CAPNS1  
  .extracellular matrix organization
.extracellular matrix disassembly
.positive regulation of cell proliferation
.proteolysis
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.extracellular exosome
.membrane
.plasma membrane
  + 2 more...
4 EBI-1026476,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-1026476,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
6 EBI-1026476,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
7 EBI-1026476,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
8 EBI-1026476,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
9 EBI-1026476,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
10 EBI-1026476,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
11 EBI-1026476,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
12 EBI-1026476,EBI-2608428 DLC1  
  .positive regulation of execution phase of apoptosis
.negative regulation of focal adhesion assembly
.negative regulation of stress fiber assembly
  + 17 more...
.SH2 domain binding
.lipid binding
.GTPase activator activity
.ruffle membrane
.cortical actin cytoskeleton
.focal adhesion
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder33
blood57
bone27
bone marrow102
brain47
cervix41
connective tissue46
ear124
embryonic tissue70
esophagus49
eye38
heart22
intestine30
kidney37
liver24
lung2
lymph22
lymph node122
mammary gland66
mouth30
muscle47
nerve64
ovary29
pancreas14
parathyroid48
pituitary gland60
placenta1006
prostate5
skin56
spleen37
stomach31
testis68
thymus62
thyroid150
trachea57
uterus51
vascular38
Health State
TissuesTPM*
normal133
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma48
colorectal tumor26
esophageal tumor57
gastrointestinal tumor42
germ cell tumor34
glioma18
head and neck tumor59
kidney tumor29
leukemia116
liver tumor20
lung tumor9
lymphoma27
non-neoplasia51
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult172
embryoid body114
blastocyst48
neonate64
fetus55
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.3
adrenal gland16.4
appendix19
bone marrow8.8
cerebral cortex19.7
colon17.4
duodenum13.7
esophagus20.4
gallbladder20.7
heart muscle11.7
kidney14.9
liver6.5
lung16.4
lymph node21.7
ovary28.5
pancreas7.3
placenta157.6
prostate15.4
salivary gland12.9
skin16.4
small intestine15.6
spleen20.5
stomach15.1
testis32.1
thyroid gland29.1
urinary bladder22.6
Tissues
TissuesExpression level
bone marrowLow
bronchusHigh
cerebral cortexLow
cervix, uterineLow
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeHigh
gallbladderLow
hippocampusLow
nasopharynxLow
placentaHigh
stomach 1Low
stomach 2Low
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*139150, gene) Ras p21 protein activator 1; RASA1OMIM
2(#608354, phenotype) Capillary malformation-arteriovenous malformationOMIM
3(#608355, phenotype) Parkes weber syndromeOMIM


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