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> Protein (NX_P20963)
Protein (NX_P20963)
Protein
Gene SymbolCD247 to neXtProt (NX_P20963)
DescriptionT-cell surface glycoprotein CD3 zeta chain
Chromosome1
Location1q24.2 (167399877 ~ 167487847) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.T cell receptor signaling pathway
.regulation of immune response
.regulation of defense response to virus by virus
  + 4 more...
.protein homodimerization activity
.identical protein binding
.transmembrane signaling receptor activity
.alpha-beta T cell receptor complex
.T cell receptor complex
.integral component of membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 16
2014-09-19protein level
2 33 16
2014-05-27protein level
2 33 16
2014-02-25protein level
2 33 16
2013-12-09protein level
2 24 16
2013-11-01protein level
2 20 16
2013-09-12protein level
2 20 16
2013-08-17protein level
2 20 16
2013-07-15protein level
2 12 9
2013-06-11protein level
2 12 9
2013-02-12protein level
2 7 18
2012-12-20protein level
2 6 18
2012-10-30protein level
2 8 18
2012-10-07protein level
2 8 9
2012-08-24protein level
2 7 9
2012-07-28protein level
2 5 9
2012-06-08protein level
2 6 9
2012-05-07protein level
2 6 9
2012-04-10protein level
2 6 9
2012-01-13protein level
2 4 9
2011-12-20protein level
2 4 9
2011-11-11protein level
2 4 9
2011-08-23protein level
2 4 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P20963-1
1 8 0 18684.6132
NX_P20963-3
1 8 0 18556.555
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1165705,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1165705,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
3 EBI-1165705,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
4 EBI-1165705,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood57
brain1
connective tissue13
heart22
intestine4
kidney9
larynx42
liver19
lymph node22
mouth30
muscle9
placenta7
prostate5
spleen93
testis2
thymus426
Health State
TissuesTPM*
normal10
head and neck tumor22
leukemia52
lymphoma13
non-neoplasia20
primitive neuroectodermal tumor of the CNS31
Developmental Stage
TissuesTPM*
adult10
fetus8
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.7
adrenal gland1.8
appendix28.6
bone marrow39.5
colon4.7
duodenum7.4
esophagus3.1
gallbladder7.1
heart muscle1.1
kidney1.1
liver3.2
lung12.3
lymph node61.2
ovary1
placenta1.5
prostate1.9
salivary gland2.2
skin1.3
small intestine9.7
spleen38
stomach8.6
thyroid gland1.3
urinary bladder11
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
lungLow
lymph nodeHigh
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*186780, gene) Cd247 antigen; CD247OMIM
2(#610163, phenotype) Immunodeficiency due to defect in cd3-zetaOMIM


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