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> Protein (NX_P21333)
Protein (NX_P21333)
Protein
Gene SymbolFLNA to neXtProt (NX_P21333)
DescriptionFilamin-A
ChromosomeX
LocationXq28 (153576892 ~ 153603006) to Ensembl
Sequene Features : Isoforms 2, Variants 304, PTMs 91 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 304 91
2014-09-19protein level
2 229 88
2014-05-27protein level
2 229 93
2014-02-25protein level
2 227 85
2013-12-09protein level
2 184 85
2013-11-01protein level
2 183 60
2013-09-12protein level
2 183 61
2013-08-17protein level
2 182 61
2013-07-15protein level
2 120 59
2013-06-11protein level
2 120 59
2013-02-12protein level
2 53 92
2012-12-20protein level
2 58 92
2012-10-30protein level
2 63 92
2012-10-07protein level
2 63 46
2012-08-24protein level
2 57 46
2012-07-28protein level
2 57 46
2012-06-08protein level
2 60 46
2012-05-07protein level
2 60 46
2012-04-10protein level
2 60 46
2012-01-13protein level
2 57 46
2011-12-20protein level
2 57 46
2011-11-11protein level
2 57 31
2011-08-23protein level
2 57 31
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21333-1
1 118 11 280563.0796
NX_P21333-2
1 118 11 279842.6899
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-350432,EBI-1187100 NRP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.facioacoustic ganglion development
.protein localization to early endosome
  + 63 more...
.metal ion binding
.vascular endothelial growth factor binding
.cytokine binding
  + 5 more...
.sorting endosome
.receptor complex
.neuronal cell body
  + 12 more...
2 EBI-350432,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
3 EBI-350432,EBI-375024 CCNB2  
  .regulation of cell cycle
.cell division
.thymus development
  + 7 more...
.N/A .membrane
.microtubule cytoskeleton
.cytosol
  + 2 more...
4 EBI-350432,EBI-703066 ITGB1  
  .negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
5 EBI-9641086,EBI-2115989 FABP1  
  .activation of mitophagy in response to mitochondrial depolarization
.cellular response to hypoxia
.cellular response to hydrogen peroxide
  + 10 more...
.bile acid binding
.antioxidant activity
.drug binding
  + 4 more...
.extracellular exosome
.apical cortex
.cytosol
  + 2 more...
6 EBI-9641086,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
7 EBI-350432,EBI-702932 ITGB7  
  .T cell migration
.leukocyte tethering or rolling
.regulation of immune response
  + 9 more...
.cell adhesion molecule binding
.metal ion binding
.virus receptor activity
.extracellular exosome
.receptor complex
.integrin alpha4-beta7 complex
  + 4 more...
8 EBI-350432,EBI-2624570 OPRM1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.cellular response to morphine
.response to growth factor
  + 30 more...
.neuropeptide binding
.morphine receptor activity
.G-protein beta-subunit binding
  + 4 more...
.membrane raft
.perikaryon
.neuron projection
  + 8 more...
9 EBI-350432,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
10 EBI-350432,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
11 EBI-9641086,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
12 EBI-350432,EBI-1175253 FOXC1  
  .negative regulation of apoptotic process involved in outflow tract morphogenesis
.positive regulation of hematopoietic stem cell differentiation
.positive regulation of hematopoietic progenitor cell differentiation
  + 39 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.DNA binding, bending
  + 7 more...
.cytoplasm
.nuclear heterochromatin
.nucleoplasm
.nucleus
13 EBI-9641086,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
14 EBI-9641086,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
15 EBI-9641086,EBI-10200920 FAM101A  
  .N/A .N/A .cytoskeleton
.cytoplasm
16 EBI-350432,EBI-2798483 PHLDB2  
  .N/A .N/A .intermediate filament cytoskeleton
.plasma membrane
.cytoplasm
17 EBI-350432,EBI-988764 ARHGAP24  
  .negative regulation of ruffle assembly
.regulation of small GTPase mediated signal transduction
.wound healing, spreading of epidermal cells
  + 4 more...
.GTPase activator activity .cell projection
.focal adhesion
.cytoskeleton
.cytosol
18 EBI-9641086,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
19 EBI-9641086,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue932
adrenal gland121
ascites251
bladder133
blood392
bone795
bone marrow328
brain96
cervix288
connective tissue93
embryonic tissue713
esophagus992
eye363
heart167
intestine754
kidney351
larynx1235
liver151
lung612
lymph158
lymph node289
mammary gland694
mouth619
muscle28
nerve836
ovary374
pancreas379
pharynx122
placenta201
prostate728
salivary gland197
skin768
spleen449
stomach397
testis85
thymus62
thyroid751
tonsil117
trachea135
uterus723
vascular77
Health State
TissuesTPM*
normal288
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor837
cervical tumor289
chondrosarcoma603
colorectal tumor853
esophageal tumor1159
gastrointestinal tumor464
germ cell tumor106
glioma401
head and neck tumor635
kidney tumor943
leukemia719
liver tumor291
lung tumor710
lymphoma96
non-neoplasia320
ovarian tumor485
pancreatic tumor704
primitive neuroectodermal tumor of the CNS165
prostate cancer337
retinoblastoma43
skin tumor933
soft tissue/muscle tissue tumor167
uterine tumor743
Developmental Stage
TissuesTPM*
adult543
embryoid body843
blastocyst797
fetus127
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue313.2
adrenal gland97.5
appendix260.6
bone marrow230.9
cerebral cortex30.5
colon304.6
duodenum122.1
esophagus518.9
gallbladder286.1
heart muscle97.7
kidney68.2
liver28.5
lung294
lymph node136.5
ovary164
pancreas39.2
placenta115.9
prostate530
salivary gland87.5
skin109.9
small intestine131.4
spleen182.6
stomach78
testis69.3
thyroid gland82.1
urinary bladder492
Tissues
TissuesExpression level
bone marrowHigh
breastMedium
cerebral cortexMedium
colonMedium
endometrium 1High
endometrium 2Medium
epididymisLow
esophagusMedium
kidneyHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryHigh
pancreasMedium
placentaHigh
skin 1Medium
skin 2Medium
smooth muscleHigh
stomach 1Low
stomach 2Low
testisLow
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300017, gene) Filamin a; FLNAOMIM
2(#300048, phenotype) Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linkedOMIM
3(#300049, phenotype) Heterotopia, periventricular, x-linked dominantOMIM
4(#300244, phenotype) Terminal osseous dysplasia; TODOMIM
5(#300321, phenotype) Fg syndrome 2; FGS2OMIM
6(#300537, phenotype) Heterotopia, periventricular, ehlers-danlos variantOMIM
7(#304120, phenotype) Otopalatodigital syndrome, type ii; OPD2OMIM
8(#305620, phenotype) Frontometaphyseal dysplasia; FMDOMIM
9(#309350, phenotype) Melnick-needles syndrome; MNSOMIM
10(#311300, phenotype) Otopalatodigital syndrome, type i; OPD1OMIM
11(#314400, phenotype) Cardiac valvular dysplasia, x-linked; CVD1OMIM


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