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> Protein (NX_P21439)
Protein (NX_P21439)
Protein
Gene SymbolABCB4 to neXtProt (NX_P21439)
DescriptionMultidrug resistance protein 3
Chromosome7
Location7q21.12 (87031013 ~ 87109751) to Ensembl
Sequene Features : Isoforms 3, Variants 235, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.small molecule metabolic process
.cellular lipid metabolic process
  + 3 more...
.ATPase activity, coupled to transmembrane movement of substances
.xenobiotic-transporting ATPase activity
.ATP binding
.extracellular exosome
.intercellular canaliculus
.integral component of membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 235 2
2014-09-19protein level
3 174 2
2014-05-27protein level
3 174 2
2014-02-25protein level
3 171 2
2013-12-09protein level
3 152 2
2013-11-01protein level
3 147 2
2013-09-12protein level
3 147 2
2013-08-17protein level
3 147 2
2013-07-15protein level
3 104 2
2013-06-11protein level
3 104 2
2013-02-12protein level
2 63 4
2012-12-20protein level
2 64 4
2012-10-30protein level
2 71 4
2012-10-07protein level
2 71 2
2012-08-24protein level
2 58 2
2012-07-28protein level
2 58 2
2012-06-08protein level
2 59 2
2012-05-07protein level
2 59 2
2012-04-10protein level
2 59 2
2012-01-13protein level
2 53 2
2011-12-20protein level
2 53 2
2011-11-11protein level
2 53 2
2011-08-23protein level
2 53 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21439-1
1 50 10 141433.4946
NX_P21439-2
0 51 10 140593.116
NX_P21439-3
1 48 10 135173.4271
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
brain1
embryonic tissue4
intestine8
kidney4
liver4
lymph45
mammary gland6
muscle9
pancreas9
testis13
Health State
TissuesTPM*
normal6
breast (mammary gland) tumor10
colorectal tumor8
kidney tumor14
leukemia31
lymphoma27
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult3
blastocyst16
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1
adrenal gland10.4
appendix2.5
colon1.4
duodenum1.5
gallbladder1.7
heart muscle5
kidney1.7
liver84.8
lymph node6.3
skin1.4
small intestine4.1
spleen5.7
urinary bladder1.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastMedium
bronchusLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderMedium
kidneyLow
liverHigh
lungLow
nasopharynxLow
pancreasLow
parathyroid glandMedium
placentaLow
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
small intestineMedium
stomach 1Medium
stomach 2Medium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*171060, gene) Atp-binding cassette, subfamily b, member 4; ABCB4OMIM
2(#600803, phenotype) Gallbladder disease 1; GBD1OMIM
3(#602347, phenotype) Cholestasis, progressive familial intrahepatic, 3; PFIC3OMIM


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