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> Protein (NX_P21583)
Protein (NX_P21583)
Protein
Gene SymbolKITLG to neXtProt (NX_P21583)
DescriptionKit ligand
Chromosome12
Location12q21.32 (88886570 ~ 88974628) to Ensembl
Sequene Features : Isoforms 3, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of mast cell proliferation
.positive regulation of peptidyl-tyrosine phosphorylation
  + 19 more...
.stem cell factor receptor binding .integral component of membrane
.plasma membrane
.cytoskeleton
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 41 9
2014-09-19protein level
3 29 9
2014-05-27protein level
3 29 9
2014-02-25protein level
3 29 9
2013-12-09protein level
3 26 9
2013-11-01protein level
3 24 9
2013-09-12protein level
3 24 9
2013-08-17protein level
3 24 9
2013-07-15protein level
3 14 9
2013-06-11protein level
3 14 9
2013-02-12protein level
3 10 24
2012-12-20protein level
3 10 24
2012-10-30protein level
3 8 24
2012-10-07protein level
3 8 9
2012-08-24protein level
3 7 9
2012-07-28protein level
3 7 9
2012-06-08protein level
3 10 9
2012-05-07protein level
3 10 9
2012-04-10protein level
3 10 9
2012-01-13protein level
3 10 9
2011-12-20protein level
3 10 9
2011-11-11protein level
3 10 9
2011-08-23protein level
3 10 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21583-1
0 10 0 30878.7884
NX_P21583-2
0 8 0 27849.262
NX_P21583-3
1 9 0 26650.3725
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1379527,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood8
bone13
brain31
connective tissue13
embryonic tissue23
esophagus49
eye4
intestine34
kidney66
liver4
lung23
mammary gland39
mouth15
muscle75
nerve64
ovary9
pancreas4
parathyroid48
pituitary gland60
placenta31
prostate58
skin33
spleen18
stomach31
testis20
thyroid21
trachea251
uterus17
vascular38
Health State
TissuesTPM*
normal27
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor8
esophageal tumor57
gastrointestinal tumor67
germ cell tumor18
glioma9
head and neck tumor7
kidney tumor43
leukemia21
liver tumor10
lung tumor38
non-neoplasia10
pancreatic tumor9
prostate cancer28
uterine tumor44
Developmental Stage
TissuesTPM*
adult30
embryoid body28
blastocyst16
neonate160
fetus10
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland7.7
appendix14.1
cerebral cortex12
colon29.7
duodenum12.8
esophagus28.4
gallbladder37.1
heart muscle9.3
kidney24
liver2.4
lung49.2
lymph node6.2
ovary8.9
pancreas3.4
placenta19.5
prostate21.4
salivary gland10.7
skin11.5
small intestine16.7
spleen4.9
stomach26.1
testis12.3
thyroid gland11.7
urinary bladder27.7
Tissues
TissuesExpression level
appendixHigh
bone marrowLow
breastHigh
cerebral cortexLow
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisLow
gallbladderMedium
kidneyLow
lungMedium
lymph nodeHigh
placentaMedium
prostateLow
rectumHigh
seminal vesicleLow
skeletal muscleMedium
skin 1High
skin 2Low
small intestineHigh
smooth muscleHigh
spleenHigh
stomach 1Medium
stomach 2High
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#145250, phenotype) Hyperpigmentation, familial progressive, 2; FPH2OMIM
2(*184745, gene) Kit ligand; KITLGOMIM
3(#611664, phenotype) Skin/hair/eye pigmentation, variation in, 7; SHEP7OMIM


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