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> Protein (NX_P21802)
Protein (NX_P21802)
Protein
Gene SymbolFGFR2 to neXtProt (NX_P21802)
DescriptionFibroblast growth factor receptor 2
Chromosome10
Location10q26.13 (123237848 ~ 123357972) to Ensembl
Sequene Features : Isoforms 23, Variants 281, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.positive regulation of ERK1 and ERK2 cascade
.regulation of ERK1 and ERK2 cascade
  + 104 more...
.protein homodimerization activity
.fibroblast growth factor binding
.heparin binding
  + 3 more...
.excitatory synapse
.intracellular membrane-bounded organelle
.cytoplasmic membrane-bounded vesicle
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
23 281 17
2014-09-19protein level
23 228 17
2014-05-27protein level
23 227 17
2014-02-25protein level
23 223 17
2013-12-09protein level
23 205 17
2013-11-01protein level
23 198 17
2013-09-12protein level
23 198 17
2013-08-17protein level
23 198 17
2013-07-15protein level
23 132 17
2013-06-11protein level
23 132 17
2013-02-12protein level
23 132 359
2012-12-20protein level
23 129 359
2012-10-30protein level
23 132 359
2012-10-07protein level
23 132 19
2012-08-24protein level
23 83 19
2012-07-28protein level
23 83 19
2012-06-08protein level
23 79 19
2012-05-07protein level
23 79 19
2012-04-10protein level
23 79 19
2012-01-13protein level
23 79 19
2011-12-20protein level
23 79 19
2011-11-11protein level
23 79 19
2011-08-23protein level
20 71 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21802-1
0 33 7 91965.5727
NX_P21802-10
3 30 7 91581.7431
NX_P21802-11
5 30 7 92673.4274
NX_P21802-12
1 30 7 86351.1139
NX_P21802-13
1 30 7 86053.9459
NX_P21802-14
1 11 0 28280.7817
NX_P21802-15
1 27 7 79160.9028
NX_P21802-16
0 33 7 92093.6672
NX_P21802-17
0 31 7 86167.0296
NX_P21802-18
0 32 7 91858.4854
NX_P21802-19
0 17 0 40588.0421
NX_P21802-2
0 32 7 86074.0014
NX_P21802-20
1 25 7 79145.4257
NX_P21802-21
2 25 7 79248.4872
NX_P21802-22
0 25 7 76373.1243
NX_P21802-23
1 26 7 79781.3555
NX_P21802-3
0 32 7 92058.6009
NX_P21802-4
1 24 7 76655.265
NX_P21802-5
0 33 7 91765.4572
NX_P21802-6
1 31 7 88123.8741
NX_P21802-7
1 31 7 91560.7614
NX_P21802-8
0 32 7 85873.8859
NX_P21802-9
3 31 7 91506.6294
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1028658,EBI-1035684 FGF10  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of canonical Wnt signaling pathway
.positive regulation of hair follicle cell proliferation
  + 99 more...
.chemoattractant activity
.heparin binding
.growth factor activity
  + 2 more...
.cell surface
.plasma membrane
.nucleus
  + 2 more...
2 EBI-1028658,EBI-698068 FGF1  
  .regulation of endothelial cell chemotaxis to fibroblast growth factor
.positive regulation of intracellular signal transduction
.mesonephric epithelium development
  + 24 more...
.S100 protein binding
.heparin binding
.growth factor activity
.fibroblast growth factor receptor binding
.cell cortex
.cytosol
.nucleolus
  + 4 more...
3 EBI-1028658,EBI-977447 FGF2  
  .positive regulation of endothelial cell chemotaxis to fibroblast growth factor
.regulation of endothelial cell chemotaxis to fibroblast growth factor
.positive regulation of sprouting angiogenesis
  + 44 more...
.chemoattractant activity
.ligand-dependent nuclear receptor transcription coactivator activity
.heparin binding
  + 3 more...
.nucleus
.extracellular space
.extracellular region
4 EBI-6354683,EBI-3937699 FGF7  
  .secretion by lung epithelial cell involved in lung growth
.regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
.positive regulation of epithelial cell proliferation involved in lung morphogenesis
  + 23 more...
.chemoattractant activity
.heparin binding
.growth factor activity
.Golgi apparatus
.extracellular region
5 EBI-1028658,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites426
bladder33
bone41
brain53
connective tissue40
ear621
embryonic tissue126
eye52
heart33
intestine12
kidney37
larynx85
liver29
lung59
mammary gland39
mouth90
muscle18
nerve64
ovary29
pancreas32
parathyroid291
pharynx24
placenta42
prostate52
skin9
stomach10
testis13
thymus25
thyroid64
trachea19
uterus56
vascular19
Health State
TissuesTPM*
normal61
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma72
colorectal tumor17
gastrointestinal tumor151
germ cell tumor53
glioma121
head and neck tumor74
kidney tumor43
liver tumor10
lung tumor9
non-neoplasia31
ovarian tumor26
pancreatic tumor28
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult65
embryoid body114
blastocyst195
fetus118
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.1
adrenal gland18.3
appendix7.2
cerebral cortex33.3
colon20.1
duodenum7.5
esophagus20.4
gallbladder27.1
kidney19.9
liver22.6
lung25.6
lymph node2.5
ovary14.2
pancreas12.8
placenta13.7
prostate16.9
salivary gland37.5
skin67.4
small intestine9.6
stomach17.5
testis7.4
thyroid gland43.3
urinary bladder14.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#101200, phenotype) Apert syndromeOMIM
2(#101600, phenotype) Pfeiffer syndromeOMIM
3(#123150, phenotype) Jackson-weiss syndrome; JWSOMIM
4(#123500, phenotype) Crouzon syndromeOMIM
5(#123790, phenotype) Beare-stevenson cutis gyrata syndrome; BSTVSOMIM
6(#149730, phenotype) Lacrimoauriculodentodigital syndrome; LADDOMIM
7(*176943, gene) Fibroblast growth factor receptor 2; FGFR2OMIM
8(#207410, phenotype) Antley-bixler syndrome without genital anomalies or disordered steroidogenesis;OMIM
9(#609579, phenotype) Scaphocephaly, maxillary retrusion, and mental retardationOMIM
10(#614592, phenotype) Bent bone dysplasia syndrome; BBDSOMIM
11gastric. NSCLC;endometrial;Crouzon;Pfeiffer;and Apert syndromesCGP


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