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> Protein (NX_P21860)
Protein (NX_P21860)
Protein
Gene SymbolERBB3 to neXtProt (NX_P21860)
DescriptionReceptor tyrosine-protein kinase erbB-3
Chromosome12
Location12q13.2 (56473641 ~ 56497289) to Ensembl
Sequene Features : Isoforms 5, Variants 218, PTMs 36 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 218 36
2014-09-19protein level
5 178 36
2014-05-27protein level
5 178 38
2014-02-25protein level
5 175 38
2013-12-09protein level
5 145 38
2013-11-01protein level
5 140 38
2013-09-12protein level
5 140 38
2013-08-17protein level
5 140 38
2013-07-15protein level
5 86 38
2013-06-11protein level
5 86 38
2013-02-12protein level
5 48 97
2012-12-20protein level
5 44 97
2012-10-30protein level
5 57 97
2012-10-07protein level
5 57 38
2012-08-24protein level
5 57 38
2012-07-28protein level
5 57 38
2012-06-08protein level
5 65 38
2012-05-07protein level
5 46 38
2012-04-10protein level
5 46 38
2012-01-13protein level
5 32 38
2011-12-20protein level
5 32 38
2011-11-11protein level
5 32 36
2011-08-23protein level
2 27 36
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21860-1
0 58 0 148001.8743
NX_P21860-2
3 6 0 20123.2915
NX_P21860-3
0 16 0 36465.2215
NX_P21860-4
1 55 0 141659.7411
NX_P21860-5
1 27 0 77376.4519
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-720706,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-720706,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
3 EBI-720706,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-720706,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-720706,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
6 EBI-720706,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
7 EBI-720706,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
8 EBI-720706,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
9 EBI-720706,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
10 EBI-720706,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
11 EBI-720706,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
12 EBI-720706,EBI-2116585 PIK3CA  
  .negative regulation of anoikis
.regulation of genetic imprinting
.negative regulation of fibroblast apoptotic process
  + 36 more...
.phosphatidylinositol-4,5-bisphosphate 3-kinase activity
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.phosphatidylinositol 3-kinase activity
  + 5 more...
.lamellipodium
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 3 more...
13 EBI-720706,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
14 EBI-720706,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
15 EBI-720706,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
16 EBI-720706,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
17 EBI-720706,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
18 EBI-720706,EBI-2460927 NRG1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of cardiac muscle cell differentiation
.positive regulation of protein targeting to mitochondrion
  + 46 more...
.ErbB-3 class receptor binding
.receptor tyrosine kinase binding
.transmembrane receptor protein tyrosine kinase activator activity
  + 5 more...
.neuromuscular junction
.axon
.apical plasma membrane
  + 6 more...
19 EBI-720706,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
20 EBI-720706,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
21 EBI-720706,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
22 EBI-720706,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
23 EBI-720706,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
24 EBI-720706,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
25 EBI-720706,EBI-7879749 SH2B3  
  .intracellular signal transduction
.embryonic hemopoiesis
.cell differentiation
.blood coagulation
.phosphate ion binding
.signaling adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites150
bladder66
bone13
brain130
cervix41
connective tissue13
ear559
embryonic tissue46
esophagus99
eye14
heart89
intestine258
kidney118
larynx170
liver112
lung2
mammary gland290
mouth589
muscle94
nerve386
ovary88
pancreas42
placenta84
prostate163
skin175
stomach146
testis11
thyroid64
trachea637
uterus47
vascular19
Health State
TissuesTPM*
normal84
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor365
cervical tumor57
chondrosarcoma12
colorectal tumor399
esophageal tumor115
gastrointestinal tumor151
germ cell tumor34
glioma111
head and neck tumor328
kidney tumor43
leukemia10
liver tumor177
lung tumor97
non-neoplasia10
ovarian tumor118
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer202
skin tumor255
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult99
embryoid body14
blastocyst32
fetus61
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.9
adrenal gland3.9
appendix8.6
bone marrow1.1
cerebral cortex18.8
colon61.1
duodenum77.6
esophagus37.4
gallbladder34.4
heart muscle2.8
kidney33.9
liver22.7
lung30
ovary1.1
pancreas17.7
placenta18.8
prostate36.9
salivary gland67.3
skin62.2
small intestine74.1
stomach69.7
testis2.3
thyroid gland6
urinary bladder31.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*190151, gene) V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; ERBB3OMIM
2(#607598, phenotype) Lethal congenital contracture syndrome 2; LCCS2OMIM


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