Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P21964)
Protein (NX_P21964)
Protein
Gene SymbolCOMT to neXtProt (NX_P21964)
DescriptionCatechol O-methyltransferase
Chromosome22
Location22q11.21 (19929130 ~ 19957498) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of sensory perception of pain
.positive regulation of homocysteine metabolic process
.negative regulation of smooth muscle cell proliferation
  + 20 more...
.catechol O-methyltransferase activity
.O-methyltransferase activity
.magnesium ion binding
.extracellular exosome
.postsynaptic membrane
.cell body
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 4
2014-09-19protein level
2 29 4
2014-05-27protein level
2 29 4
2014-02-25protein level
2 29 4
2013-12-09protein level
2 16 4
2013-11-01protein level
2 16 2
2013-09-12protein level
2 16 2
2013-08-17protein level
2 16 2
2013-07-15protein level
2 12 1
2013-06-11protein level
2 12 1
2013-02-12protein level
2 11 2
2012-12-20protein level
2 11 2
2012-10-30protein level
2 15 2
2012-10-07protein level
2 15 1
2012-08-24protein level
2 14 1
2012-07-28protein level
2 14 1
2012-06-08protein level
2 15 1
2012-05-07protein level
2 15 1
2012-04-10protein level
2 15 1
2012-01-13protein level
2 12 1
2011-12-20protein level
2 12 1
2011-11-11protein level
2 12 1
2011-08-23protein level
2 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P21964-1
2 12 0 30017.5454
NX_P21964-2
0 12 0 24433.3099
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10200977,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
2 EBI-10200977,EBI-994813 CDC27  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 6 more...
.protein phosphatase binding .cytosol
.spindle
.centrosome
  + 4 more...
3 EBI-10200977,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-10200977,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
5 EBI-10200977,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood16
bone27
brain46
embryonic tissue37
esophagus49
eye62
heart89
intestine77
kidney80
liver4
lung62
lymph45
lymph node11
mammary gland72
mouth15
muscle9
nerve64
ovary39
pancreas84
parathyroid242
placenta60
prostate131
skin85
spleen37
stomach10
testis25
thymus12
thyroid21
uterus47
vascular58
Health State
TissuesTPM*
normal55
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma193
colorectal tumor186
esophageal tumor57
gastrointestinal tumor135
germ cell tumor41
glioma167
head and neck tumor14
kidney tumor29
leukemia21
liver tumor10
lung tumor19
lymphoma69
non-neoplasia41
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS55
prostate cancer134
skin tumor71
uterine tumor66
Developmental Stage
TissuesTPM*
adult111
blastocyst113
neonate32
fetus62
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.9
adrenal gland99.7
appendix44.7
bone marrow42.2
cerebral cortex54.5
colon32.9
duodenum40.7
esophagus73.7
gallbladder52.4
heart muscle50.2
kidney52.7
liver64
lung77.7
lymph node45.7
ovary79.5
pancreas32.5
placenta100.7
prostate70
salivary gland73.6
skin50.1
small intestine41.5
spleen50.8
stomach53.4
testis54.5
thyroid gland45.3
urinary bladder80.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisHigh
esophagusMedium
fallopian tubeLow
gallbladderMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxLow
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#103780, phenotype) Alcohol dependenceOMIM
2(+116790, gene/phenotype) Catechol-o-methyltransferase; COMTOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center