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> Protein (NX_P22059)
Protein (NX_P22059)
Protein
Gene SymbolOSBP to neXtProt (NX_P22059)
DescriptionOxysterol-binding protein 1
Chromosome11
Location11q12.1 (59341871 ~ 59383617) to Ensembl
Sequene Features : Isoforms 1, Variants 83, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of growth of symbiont in host
.lipid transport
.protein domain specific binding
.oxysterol binding
.cell junction
.membrane
.Golgi apparatus
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 83 11
2014-09-19protein level
1 57 11
2014-05-27protein level
1 57 11
2014-02-25protein level
1 57 12
2013-12-09protein level
1 44 12
2013-11-01protein level
1 41 12
2013-09-12protein level
1 41 12
2013-08-17protein level
1 41 12
2013-07-15protein level
1 29 12
2013-06-11protein level
1 29 12
2013-02-12protein level
1 10 12
2012-12-20protein level
1 10 12
2012-10-30protein level
1 11 12
2012-10-07protein level
1 11 12
2012-08-24protein level
1 6 12
2012-07-28protein level
1 6 12
2012-06-08protein level
1 6 12
2012-05-07protein level
1 6 12
2012-04-10protein level
1 6 12
2012-01-13protein level
1 4 12
2011-12-20protein level
1 4 12
2011-11-11protein level
1 4 12
2011-08-23protein level
1 4 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22059-1
32 0 2 89364.2971
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2681902,EBI-744771 FKBP6  
  .chaperone-mediated protein folding
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 6 more...
.Hsp90 protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.cytosol
.endoplasmic reticulum membrane
.cytoplasm
.synaptonemal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites50
bladder66
blood49
bone97
bone marrow61
brain26
connective tissue40
ear62
embryonic tissue42
eye114
intestine51
kidney52
larynx42
liver68
lung65
lymph22
lymph node89
mammary gland6
mouth30
muscle9
ovary29
pancreas70
parathyroid97
pharynx49
placenta74
prostate21
skin56
spleen37
stomach41
testis43
thymus12
thyroid107
trachea77
umbilical cord72
uterus38
vascular19
Health State
TissuesTPM*
normal44
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
chondrosarcoma96
colorectal tumor62
gastrointestinal tumor67
germ cell tumor34
glioma46
head and neck tumor67
kidney tumor43
leukemia84
liver tumor41
lung tumor58
lymphoma27
non-neoplasia20
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma86
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult46
embryoid body71
blastocyst32
neonate32
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.5
adrenal gland35.6
appendix16.9
bone marrow21.5
cerebral cortex16.5
colon25.5
duodenum25.4
esophagus19.2
gallbladder20.5
heart muscle19
kidney32
liver29
lung17.3
lymph node17.7
ovary21.2
pancreas17.3
placenta24.9
prostate22.1
salivary gland20.8
skin19.4
small intestine22.9
spleen13.8
stomach23.5
testis19.2
thyroid gland32.3
urinary bladder21.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*167040, gene) Oxysterol-binding protein; OSBPOMIM


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