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> Protein (NX_P22234)
Protein (NX_P22234)
Protein
Gene SymbolPAICS to neXtProt (NX_P22234)
DescriptionMultifunctional protein ADE2
Chromosome4
Location4q12 (57301907 ~ 57327534) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.purine ribonucleoside monophosphate biosynthetic process
  + 3 more...
.identical protein binding
.ATP binding
.phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
.phosphoribosylaminoimidazole carboxylase activity
.extracellular exosome
.membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 21
2014-09-19protein level
2 28 21
2014-05-27protein level
2 28 21
2014-02-25protein level
2 28 20
2013-12-09protein level
2 18 21
2013-11-01protein level
2 18 17
2013-09-12protein level
2 18 17
2013-08-17protein level
2 18 16
2013-07-15protein level
2 11 8
2013-06-11protein level
2 11 8
2013-02-12protein level
2 4 18
2012-12-20protein level
2 6 18
2012-10-30protein level
2 10 18
2012-10-07protein level
2 10 9
2012-08-24protein level
2 10 9
2012-07-28protein level
2 10 9
2012-06-08protein level
2 16 9
2012-05-07protein level
2 16 9
2012-04-10protein level
2 16 9
2012-01-13protein level
2 10 9
2011-12-20protein level
2 10 9
2011-11-11protein level
2 10 9
2011-08-23protein level
2 10 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22234-1
1 18 0 47049.003
NX_P22234-2
1 18 0 47927.4614
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712261,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
2 EBI-712261,EBI-740486 NUDT18  
  .nucleobase-containing small molecule metabolic process
.GDP catabolic process
.dGDP catabolic process
  + 3 more...
.8-hydroxy-dADP phosphatase activity
.8-oxo-GDP phosphatase activity
.8-oxo-dGDP phosphatase activity
.magnesium ion binding
.cytosol
3 EBI-712261,EBI-739909 L3MBTL2  
  .chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.histone binding
.methylated histone binding
.zinc ion binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites502
bladder33
blood212
bone27
bone marrow184
brain118
cervix20
connective tissue114
embryonic tissue432
esophagus248
eye196
heart78
intestine30
kidney161
larynx42
liver228
lung2
lymph428
lymph node144
mammary gland13
mouth120
muscle18
nerve64
ovary137
pancreas37
parathyroid48
pharynx24
pituitary gland968
placenta166
prostate163
salivary gland49
skin4
spleen18
stomach303
testis188
thymus12
thyroid21
tonsil117
trachea193
uterus172
vascular135
Health State
TissuesTPM*
normal3
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor214
cervical tumor28
chondrosarcoma96
colorectal tumor53
esophageal tumor231
gastrointestinal tumor8
germ cell tumor387
glioma149
head and neck tumor67
kidney tumor116
leukemia328
liver tumor416
lung tumor136
lymphoma360
non-neoplasia72
ovarian tumor157
pancreatic tumor57
primitive neuroectodermal tumor of the CNS236
prostate cancer240
retinoblastoma624
skin tumor279
soft tissue/muscle tissue tumor271
uterine tumor144
Developmental Stage
TissuesTPM*
adult6
embryoid body314
blastocyst634
neonate160
fetus5
infant382
juvenile665
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.4
adrenal gland33.7
appendix30.6
bone marrow22.7
cerebral cortex24.7
colon32.2
duodenum25
esophagus26.3
gallbladder15.7
heart muscle13
kidney25.5
liver37
lung10.4
lymph node38.4
ovary23
pancreas9.3
placenta33.2
prostate24.3
salivary gland16.8
skin29.6
small intestine23.6
spleen15.2
stomach18.3
testis29.4
thyroid gland27.1
urinary bladder22.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*172439, gene) Phosphoribosylaminoimidazole carboxylase; PAICSOMIM


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