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> Protein (NX_P22392)
Protein (NX_P22392)
Protein
Gene SymbolNME2 to neXtProt (NX_P22392)
DescriptionNucleoside diphosphate kinase B
Chromosome17
Location17q21.33 (49230920 ~ 49249108) to Ensembl
Sequene Features : Isoforms 2, Variants 16, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.nucleobase-containing small molecule metabolic process
.positive regulation of epithelial cell proliferation
  + 16 more...
.metal ion binding
.ATP binding
.protein histidine kinase activity
  + 3 more...
.cell periphery
.extracellular exosome
.lamellipodium
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 16 4
2014-09-19protein level
2 13 4
2014-05-27protein level
2 13 15
2014-02-25protein level
2 13 15
2013-12-09protein level
2 7 15
2013-11-01protein level
2 7 7
2013-09-12protein level
2 7 8
2013-08-17protein level
2 7 8
2013-07-15protein level
2 6 6
2013-06-11protein level
2 6 6
2013-02-12protein level
2 4 27
2012-12-20protein level
2 3 27
2012-10-30protein level
2 4 27
2012-10-07protein level
2 4 17
2012-08-24protein level
2 3 17
2012-07-28protein level
2 3 17
2012-06-08protein level
2 0 17
2012-05-07protein level
2 3 17
2012-04-10protein level
2 3 17
2012-01-13protein level
2 3 17
2011-12-20protein level
2 3 17
2011-11-11protein level
2 3 16
2011-08-23protein level
2 3 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22392-1
0 5 4 17286.8917
NX_P22392-2
0 5 11 30117.5466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713693,EBI-2127367 ITGB1BP1  
  .regulation of integrin-mediated signaling pathway
.negative regulation of substrate adhesion-dependent cell spreading
.negative regulation of protein targeting to membrane
  + 37 more...
.protein complex binding
.protein transporter activity
.integrin binding
.GDP-dissociation inhibitor activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 8 more...
2 EBI-713693,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland333
ascites451
bladder234
blood319
bone363
bone marrow123
brain126
cervix164
connective tissue234
ear62
embryonic tissue366
esophagus198
eye411
heart245
intestine262
kidney208
larynx170
liver467
lung310
lymph541
lymph node133
mammary gland416
mouth75
muscle141
nerve193
ovary285
pancreas281
parathyroid291
pharynx441
pituitary gland363
placenta158
prostate274
salivary gland444
skin574
stomach271
testis119
thymus25
thyroid85
tonsil117
umbilical cord508
uterus215
vascular174
Health State
TissuesTPM*
normal186
adrenal tumor632
bladder carcinoma113
breast (mammary gland) tumor537
cervical tumor144
chondrosarcoma169
colorectal tumor302
esophageal tumor231
gastrointestinal tumor312
germ cell tumor208
glioma93
head and neck tumor179
kidney tumor261
leukemia317
liver tumor374
lung tumor535
lymphoma443
non-neoplasia31
ovarian tumor288
pancreatic tumor352
primitive neuroectodermal tumor of the CNS283
prostate cancer471
retinoblastoma990
skin tumor813
soft tissue/muscle tissue tumor367
uterine tumor177
Developmental Stage
TissuesTPM*
adult236
embryoid body528
blastocyst195
neonate225
fetus156
infant170
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue143.8
adrenal gland155.6
appendix137
bone marrow112.2
cerebral cortex61
colon198.5
duodenum138.5
esophagus205.6
gallbladder119.1
heart muscle130.3
kidney129.4
liver83.9
lung94.2
lymph node155.9
ovary212.3
pancreas123.1
placenta113.9
prostate120.7
salivary gland164
skin138.8
small intestine131.5
spleen114.8
stomach149.1
testis49.7
thyroid gland126.9
urinary bladder203
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*156491, gene) Nonmetastatic cells 2, protein expressed in; NME2OMIM


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