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> Protein (NX_P22415)
Protein (NX_P22415)
Protein
Gene SymbolUSF1 to neXtProt (NX_P22415)
DescriptionUpstream stimulatory factor 1
Chromosome1
Location1q23.3 (161009041 ~ 161015767) to Ensembl
Sequene Features : Isoforms 2, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lipid homeostasis
.negative regulation of fibrinolysis
.carbon catabolite regulation of transcription
  + 11 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.bHLH transcription factor binding
  + 6 more...
.transcription factor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 41 5
2014-09-19protein level
2 21 5
2014-05-27protein level
2 21 6
2014-02-25protein level
2 21 6
2013-12-09protein level
2 18 6
2013-11-01protein level
2 17 6
2013-09-12protein level
2 17 6
2013-08-17protein level
1 17 6
2013-07-15protein level
1 10 5
2013-06-11protein level
1 10 5
2013-02-12protein level
1 4 0
2012-12-20protein level
1 4 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22415-1
2 5 2 33517.5375
NX_P22415-2
0 5 2 27355.542
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1054489,EBI-744510 FOSL1  
  .positive regulation of DNA-templated transcription, initiation
.placenta blood vessel development
.response to cAMP
  + 22 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.neuron projection
.presynaptic membrane
.cytosol
  + 2 more...
2 EBI-1054489,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-1054489,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone marrow20
brain6
embryonic tissue9
heart22
intestine21
liver4
mammary gland39
ovary9
pancreas4
prostate10
skin28
stomach10
testis2
thyroid257
uterus12
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor42
colorectal tumor26
gastrointestinal tumor8
glioma18
head and neck tumor29
leukemia52
liver tumor10
ovarian tumor13
pancreatic tumor9
prostate cancer9
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult17
embryoid body28
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.5
adrenal gland30.8
appendix54.8
bone marrow67.6
cerebral cortex29.8
colon34.4
duodenum37.9
esophagus21.6
gallbladder32.9
heart muscle23.6
kidney23.7
liver20.7
lung51.1
lymph node69.4
ovary31.8
pancreas13.3
placenta32.7
prostate25.4
salivary gland25.8
skin33.2
small intestine38.9
spleen70.6
stomach34.8
testis21.1
thyroid gland23.9
urinary bladder41.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#144250, phenotype) Hyperlipidemia, familial combined; FCHLOMIM
2(*191523, gene) Upstream stimulatory factor 1; USF1OMIM
3(#602491, phenotype) Hyperlipidemia, combined, 1OMIM


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