Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P22607)
Protein (NX_P22607)
Protein
Gene SymbolFGFR3 to neXtProt (NX_P22607)
DescriptionFibroblast growth factor receptor 3
Chromosome4
Location4p16.3 (1795034 ~ 1810599) to Ensembl
Sequene Features : Isoforms 4, Variants 179, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.fibroblast growth factor receptor apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.cochlea development
  + 51 more...
.fibroblast growth factor binding
.ATP binding
.fibroblast growth factor-activated receptor activity
.protein tyrosine kinase activity
.perinuclear region of cytoplasm
.transport vesicle
.cell surface
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 179 13
2014-09-19protein level
4 156 13
2014-05-27protein level
4 151 13
2014-02-25protein level
4 150 13
2013-12-09protein level
4 124 13
2013-11-01protein level
4 120 13
2013-09-12protein level
4 120 13
2013-08-17protein level
4 120 13
2013-07-15protein level
4 91 13
2013-06-11protein level
4 91 13
2013-02-12protein level
4 71 44
2012-12-20protein level
4 72 44
2012-10-30protein level
4 76 44
2012-10-07protein level
4 76 13
2012-08-24protein level
4 76 13
2012-07-28protein level
4 76 13
2012-06-08protein level
4 56 13
2012-05-07protein level
4 56 13
2012-04-10protein level
4 56 13
2012-01-13protein level
4 52 13
2011-12-20protein level
4 52 13
2011-11-11protein level
4 52 13
2011-08-23protein level
4 47 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22607-1
0 27 9 87653.8822
NX_P22607-2
5 25 9 88101.2098
NX_P22607-3
1 23 9 75647.6773
NX_P22607-4
7 24 6 85029.0953
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348399,EBI-698068 FGF1  
  .regulation of endothelial cell chemotaxis to fibroblast growth factor
.positive regulation of intracellular signal transduction
.mesonephric epithelium development
  + 24 more...
.S100 protein binding
.heparin binding
.growth factor activity
.fibroblast growth factor receptor binding
.cell cortex
.cytosol
.nucleolus
  + 4 more...
2 EBI-348399,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone13
bone marrow20
brain22
connective tissue26
embryonic tissue79
eye28
heart11
intestine38
kidney52
larynx85
lung35
nerve64
ovary9
pancreas9
placenta3
prostate26
skin52
stomach20
testis9
uterus8
Health State
TissuesTPM*
normal20
bladder carcinoma113
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor33
germ cell tumor53
glioma18
head and neck tumor14
lung tumor58
non-neoplasia62
ovarian tumor13
pancreatic tumor19
skin tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult21
embryoid body14
blastocyst195
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.2
bone marrow1.3
cerebral cortex27.3
colon8.8
duodenum21.9
esophagus32.4
gallbladder9.9
heart muscle1.4
kidney29.6
liver9.5
lung10.6
pancreas29
placenta9.3
prostate7.1
skin246.9
small intestine17.3
spleen3.4
stomach9
testis20.5
urinary bladder17.8
Tissues
TissuesExpression level
adrenal glandLow
bone marrowMedium
cerebellumMedium
cerebral cortexMedium
colonLow
epididymisLow
esophagusMedium
hippocampusHigh
liverLow
nasopharynxMedium
oral mucosaLow
parathyroid glandLow
placentaLow
rectumLow
skin 1High
skin 2High
small intestineLow
testisMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#100800, phenotype) Achondroplasia; ACHOMIM
2(#109800, phenotype) Bladder cancerOMIM
3(*134934, gene) Fibroblast growth factor receptor 3; FGFR3OMIM
4(#146000, phenotype) Hypochondroplasia; HCHOMIM
5(#149730, phenotype) Lacrimoauriculodentodigital syndrome; LADDOMIM
6(#162900, phenotype) Nevus, epidermalOMIM
7(#182000, phenotype) Keratosis, seborrheicOMIM
8(#187600, phenotype) Thanatophoric dysplasia, type i; TD1OMIM
9(#187601, phenotype) Thanatophoric dysplasia, type ii; TD2OMIM
10(#254500, phenotype) Myeloma, multipleOMIM
11(#273300, phenotype) Testicular germ cell tumor; TGCTOMIM
12(#602849, phenotype) Muenke syndrome; MNKESOMIM
13(#603956, phenotype) Cervical cancerOMIM
14(#610474, phenotype) Camptodactyly, tall stature, and hearing loss syndromeOMIM
15(#612247, phenotype) Crouzon syndrome with acanthosis nigricans; CANOMIM
16bladder;multiple myeloma;T-cell lymphoma;Hypochondroplasia;Thanatophoric dysplasiaCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center