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> Protein (NX_P22681)
Protein (NX_P22681)
Protein
Gene SymbolCBL to neXtProt (NX_P22681)
DescriptionE3 ubiquitin-protein ligase CBL
Chromosome11
Location11q23.3 (119076752 ~ 119178859) to Ensembl
Sequene Features : Isoforms 1, Variants 187, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 187 23
2014-09-19protein level
1 165 23
2014-05-27protein level
1 164 23
2014-02-25protein level
1 161 24
2013-12-09protein level
1 145 24
2013-11-01protein level
1 136 24
2013-09-12protein level
1 136 24
2013-08-17protein level
1 136 24
2013-07-15protein level
1 100 18
2013-06-11protein level
1 100 18
2013-02-12protein level
1 80 16
2012-12-20protein level
1 80 16
2012-10-30protein level
1 85 16
2012-10-07protein level
1 85 16
2012-08-24protein level
1 81 16
2012-07-28protein level
1 81 16
2012-06-08protein level
1 33 16
2012-05-07protein level
1 33 16
2012-04-10protein level
1 33 16
2012-01-13protein level
1 25 16
2011-12-20protein level
1 25 16
2011-11-11protein level
1 24 16
2011-08-23protein level
1 24 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22681-1
37 0 3 99568.9768
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-518228,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-518228,EBI-7507432 SH2B2  
  .regulation of JAK-STAT cascade
.intracellular signal transduction
.positive regulation of signal transduction
  + 3 more...
.JAK pathway signal transduction adaptor activity
.SH3/SH2 adaptor activity
.signal transducer activity
.plasma membrane
.cytosol
.cytoplasm
3 EBI-518228,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
4 EBI-518228,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
5 EBI-518228,EBI-1028226 NTRK1  
  .cellular response to nerve growth factor stimulus
.cellular response to nicotine
.positive regulation of ERK1 and ERK2 cascade
  + 41 more...
.nerve growth factor binding
.neurotrophin binding
.protein homodimerization activity
  + 3 more...
.receptor complex
.protein complex
.neuronal cell body
  + 11 more...
6 EBI-518228,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
7 EBI-518228,EBI-9834454 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
8 EBI-518228,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
9 EBI-518228,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
10 EBI-518228,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
11 EBI-518228,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
12 EBI-518228,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
13 EBI-518228,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
14 EBI-518228,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
15 EBI-518228,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
16 EBI-518228,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
17 EBI-518228,EBI-4303189 F2RL1  
  .positive regulation of interleukin-6 secretion
.positive regulation of interleukin-8 secretion
.positive regulation of renin secretion into blood stream
  + 46 more...
.G-protein beta-subunit binding
.thrombin receptor activity
.receptor binding
  + 3 more...
.pseudopodium
.integral component of plasma membrane
.plasma membrane
  + 2 more...
18 EBI-518228,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
19 EBI-518228,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
20 EBI-518228,EBI-602041 ITSN1  
  .apoptotic signaling pathway
.positive regulation of protein kinase B signaling
.regulation of small GTPase mediated signal transduction
  + 8 more...
.proline-rich region binding
.protein complex scaffold
.kinase activator activity
  + 3 more...
.synapse
.neuron projection
.endocytic vesicle
  + 5 more...
21 EBI-518228,EBI-7358775 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
22 EBI-518228,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
23 EBI-518228,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
24 EBI-518228,EBI-354861 SPRY4  
  .negative regulation of MAP kinase activity
.multicellular organismal development
.N/A .ruffle membrane
.focal adhesion
.Golgi apparatus
.cytoplasm
25 EBI-518228,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood40
bone69
bone marrow61
brain32
cervix20
connective tissue6
ear124
embryonic tissue46
eye38
heart44
intestine34
kidney33
larynx42
liver9
lung50
lymph22
lymph node155
mammary gland92
mouth15
muscle47
nerve64
pancreas51
placenta28
prostate15
salivary gland49
skin42
spleen112
stomach10
testis75
thymus12
trachea19
uterus38
vascular38
Health State
TissuesTPM*
normal45
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma48
colorectal tumor35
gastrointestinal tumor16
germ cell tumor60
head and neck tumor7
kidney tumor29
leukemia63
lung tumor19
lymphoma27
non-neoplasia41
pancreatic tumor76
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body57
blastocyst48
fetus64
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.8
adrenal gland3.4
appendix9.5
bone marrow4.7
cerebral cortex5.5
colon4.4
duodenum3.4
esophagus4.3
gallbladder4.1
heart muscle2.6
kidney3.2
liver1.4
lung5.8
lymph node10.5
ovary2.8
pancreas1.3
placenta5.7
prostate2.5
salivary gland1.8
skin4.4
small intestine4
spleen8.3
stomach4.2
testis17.3
thyroid gland4.2
urinary bladder5.4
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
cerebellumLow
cerebral cortexLow
colonLow
epididymisLow
hippocampusLow
kidneyLow
lateral ventricleLow
lungMedium
lymph nodeMedium
ovaryLow
soft tissue 1Low
spleenMedium
testisMedium
tonsilMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*165360, gene) Cas-br-m murine ecotropic retroviral transforming sequence homolog;OMIM
2(#613563, phenotype) Noonan syndrome-like disorder with or without juvenile myelomonocyticOMIM
3acute myelogenous leukemia;juvenile myelomonocytic leukemia;myelodysplastic syndromeCGP


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