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> Protein (NX_P22694)
Protein (NX_P22694)
Protein
Gene SymbolPRKACB to neXtProt (NX_P22694)
DescriptioncAMP-dependent protein kinase catalytic subunit beta
Chromosome1
Location1p31.1 (84543745 ~ 84704181) to Ensembl
Sequene Features : Isoforms 10, Variants 55, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.response to clozapine
.cellular response to glucagon stimulus
  + 26 more...
.ubiquitin protein ligase binding
.ATP binding
.cAMP-dependent protein kinase activity
.magnesium ion binding
.ciliary base
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 55 11
2014-09-19protein level
10 36 11
2014-05-27protein level
10 36 12
2014-02-25protein level
10 39 12
2013-12-09protein level
10 34 12
2013-11-01protein level
10 33 12
2013-09-12protein level
10 33 12
2013-08-17protein level
10 33 12
2013-07-15protein level
10 21 4
2013-06-11protein level
10 21 4
2013-02-12protein level
9 5 38
2012-12-20protein level
9 5 38
2012-10-30protein level
9 5 38
2012-10-07protein level
9 5 6
2012-08-24protein level
9 5 6
2012-07-28protein level
9 5 6
2012-06-08protein level
9 6 6
2012-05-07protein level
9 6 6
2012-04-10protein level
8 6 6
2012-01-13protein level
8 6 6
2011-12-20protein level
8 6 6
2011-11-11protein level
8 6 6
2011-08-23protein level
8 6 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22694-1
0 7 10 40596.8932
NX_P22694-10
0 5 9 36955.7011
NX_P22694-2
2 5 10 46206.5422
NX_P22694-3
0 5 10 39451.3652
NX_P22694-4
0 5 10 39354.2764
NX_P22694-5
0 6 10 40920.9664
NX_P22694-6
0 6 10 41270.093
NX_P22694-7
0 6 10 41020.0345
NX_P22694-8
0 6 6 29677.3573
NX_P22694-9
0 6 10 41369.1611
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2679622,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
2 EBI-2679622,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
3 EBI-5258763,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood65
bone marrow328
brain650
cervix82
connective tissue20
ear186
embryonic tissue32
esophagus49
eye90
heart67
intestine68
kidney104
larynx85
liver19
lung38
lymph node300
mammary gland13
mouth45
muscle112
nerve257
pancreas117
parathyroid48
pharynx49
pituitary gland60
placenta28
prostate200
salivary gland98
skin75
spleen18
stomach20
testis57
thymus401
thyroid107
trachea714
uterus112
vascular58
Health State
TissuesTPM*
normal229
bladder carcinoma113
cervical tumor115
colorectal tumor35
esophageal tumor57
gastrointestinal tumor8
germ cell tumor106
glioma83
head and neck tumor74
kidney tumor101
leukemia84
liver tumor20
lung tumor9
non-neoplasia113
pancreatic tumor47
prostate cancer327
retinoblastoma64
skin tumor95
soft tissue/muscle tissue tumor31
uterine tumor77
Developmental Stage
TissuesTPM*
adult71
embryoid body57
blastocyst48
neonate32
fetus166
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.8
adrenal gland51.8
appendix29
bone marrow9.6
cerebral cortex178.5
colon54
duodenum10.7
esophagus18.1
gallbladder30
heart muscle21.2
kidney21
liver10.7
lung13.1
lymph node42.7
ovary19.4
pancreas14.1
placenta9.4
prostate30.2
salivary gland61.4
skin3.9
small intestine11.9
spleen32
stomach31.9
testis9.8
thyroid gland29.5
urinary bladder38.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176892, gene) Protein kinase, camp-dependent, catalytic, beta; PRKACBOMIM


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