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> Protein (NX_P22736)
Protein (NX_P22736)
Protein
Gene SymbolNR4A1 to neXtProt (NX_P22736)
DescriptionNuclear receptor subfamily 4 group A member 1
Chromosome12
Location12q13.13 (52416616 ~ 52453291) to Ensembl
Sequene Features : Isoforms 3, Variants 80, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 80 2
2014-09-19protein level
3 55 2
2014-05-27protein level
3 55 2
2014-02-25protein level
3 55 2
2013-12-09protein level
3 34 2
2013-11-01protein level
3 32 2
2013-09-12protein level
3 32 2
2013-08-17protein level
2 31 2
2013-07-15protein level
2 21 2
2013-06-11protein level
2 21 2
2013-02-12protein level
2 11 4
2012-12-20protein level
2 10 4
2012-10-30protein level
2 13 4
2012-10-07protein level
2 13 2
2012-08-24protein level
2 13 2
2012-07-28protein level
2 13 2
2012-06-08protein level
2 16 2
2012-05-07protein level
2 13 2
2012-04-10protein level
2 13 2
2012-01-13protein level
1 10 2
2011-12-20protein level
1 10 2
2011-11-11protein level
1 10 2
2011-08-23protein level
1 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22736-1
0 19 2 64422.0394
NX_P22736-2
1 18 2 65955.7462
NX_P22736-3
2 8 0 33732.7581
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-721550,EBI-1051556 CUTA  
  .response to metal ion
.protein localization
.enzyme binding .extracellular exosome
.membrane
2 EBI-721550,EBI-355007 TUBB4A  
  .protein polymerization
.'de novo' posttranslational protein folding
.cellular protein metabolic process
  + 5 more...
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.extracellular exosome
.myelin sheath
.neuronal cell body
  + 5 more...
3 EBI-721550,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-721550,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
5 EBI-721550,EBI-3926629 GK  
  .glycerol-3-phosphate biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 6 more...
.ATP binding
.glycerol kinase activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
  + 2 more...
6 EBI-721550,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
7 EBI-721550,EBI-352602 MATR3  
  .posttranscriptional regulation of gene expression .poly(A) RNA binding
.zinc ion binding
.structural molecule activity
.nucleotide binding
.nuclear matrix
.membrane
.nucleoplasm
.nuclear inner membrane
8 EBI-721550,EBI-748201 VASP  
  .protein homotetramerization
.T cell receptor signaling pathway
.cell junction assembly
  + 4 more...
.profilin binding .extracellular exosome
.filopodium membrane
.lamellipodium membrane
  + 6 more...
9 EBI-721550,EBI-745859 CDKN2D  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of protein serine/threonine kinase activity
.autophagic cell death
  + 13 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
10 EBI-721550,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
11 EBI-721550,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
12 EBI-721550,EBI-10290053 PGBD1  
  .N/A .scavenger receptor activity
.sequence-specific DNA binding transcription factor activity
.membrane
.nucleus
13 EBI-721550,EBI-2687890 ANKIB1  
  .N/A .zinc ion binding .N/A
14 EBI-721550,EBI-310731 PLXND1  
  .semaphorin-plexin signaling pathway
.dichotomous subdivision of terminal units involved in salivary gland branching
.regulation of angiogenesis
  + 8 more...
.protein domain specific binding
.semaphorin receptor activity
.lamellipodium
.integral component of plasma membrane
.plasma membrane
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland425
bladder167
blood49
bone69
bone marrow20
brain43
cervix61
connective tissue6
esophagus148
eye19
heart67
intestine43
kidney14
larynx42
liver4
lung50
lymph67
lymph node22
mammary gland59
muscle37
nerve1351
ovary128
pancreas56
parathyroid48
placenta21
prostate89
skin66
stomach52
testis22
thymus25
thyroid171
trachea57
uterus112
Health State
TissuesTPM*
normal51
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma289
colorectal tumor26
esophageal tumor173
gastrointestinal tumor8
glioma9
head and neck tumor14
kidney tumor58
leukemia21
liver tumor10
lung tumor48
lymphoma27
non-neoplasia82
ovarian tumor170
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer48
skin tumor63
soft tissue/muscle tissue tumor7
uterine tumor221
Developmental Stage
TissuesTPM*
adult38
fetus5
infant42
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue214.9
adrenal gland564.1
appendix89.6
bone marrow19.7
cerebral cortex26.4
colon91.6
duodenum32.6
esophagus126
gallbladder416.7
heart muscle87.5
kidney107
liver45
lung126
lymph node51.2
ovary625.3
pancreas42.8
placenta39.7
prostate290.1
salivary gland111.3
skin5.6
small intestine47.8
spleen33.4
stomach58.5
testis26.4
thyroid gland143.1
urinary bladder289.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*139139, gene) Nuclear receptor subfamily 4, group a, member 1; NR4A1OMIM


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