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	> Protein (NX_P22736) Protein (NX_P22736) Protein Gene Symbol NR4A1 to neXtProt (NX_P22736) Description Nuclear receptor subfamily 4 group A member 1 Chromosome 12 Location 12q13.13 (52416616 ~ 52453291) to Ensembl Sequene Features : Isoforms 3, Variants 80, PTMs 2 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .phosphatidylinositol-mediated signaling .neurotrophin TRK receptor signaling pathway .positive regulation of transcription from RNA polymerase II promoter   + 13 more... .sequence-specific DNA binding .zinc ion binding .ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity   + 2 more... .nuclear membrane .cytoplasm .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 3 80 2 2014-09-19 protein level 3 55 2 2014-05-27 protein level 3 55 2 2014-02-25 protein level 3 55 2 2013-12-09 protein level 3 34 2 2013-11-01 protein level 3 32 2 2013-09-12 protein level 3 32 2 2013-08-17 protein level 2 31 2 2013-07-15 protein level 2 21 2 2013-06-11 protein level 2 21 2 2013-02-12 protein level 2 11 4 2012-12-20 protein level 2 10 4 2012-10-30 protein level 2 13 4 2012-10-07 protein level 2 13 2 2012-08-24 protein level 2 13 2 2012-07-28 protein level 2 13 2 2012-06-08 protein level 2 16 2 2012-05-07 protein level 2 13 2 2012-04-10 protein level 2 13 2 2012-01-13 protein level 1 10 2 2011-12-20 protein level 1 10 2 2011-11-11 protein level 1 10 2 2011-08-23 protein level 1 10 2 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_P22736-1 0 19 2 64422.0394 NX_P22736-2 1 18 2 65955.7462 NX_P22736-3 2 8 0 33732.7581 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-721550,EBI-1051556 CUTA     .response to metal ion .protein localization .enzyme binding .extracellular exosome .membrane 2 EBI-721550,EBI-355007 TUBB4A     .protein polymerization .'de novo' posttranslational protein folding .cellular protein metabolic process   + 5 more... .GTP binding .structural constituent of cytoskeleton .GTPase activity .extracellular exosome .myelin sheath .neuronal cell body   + 5 more... 3 EBI-721550,EBI-366083 TP53     .positive regulation of intrinsic apoptotic signaling pathway .positive regulation of reactive oxygen species metabolic process .negative regulation of reactive oxygen species metabolic process   + 99 more... .protein phosphatase 2A binding .chaperone binding .protein N-terminus binding   + 27 more... .protein complex .PML body .nuclear matrix   + 11 more... 4 EBI-721550,EBI-77694 BCL2     .positive regulation of intrinsic apoptotic signaling pathway .negative regulation of intrinsic apoptotic signaling pathway .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand   + 111 more... .BH3 domain binding .protein heterodimerization activity .sequence-specific DNA binding   + 6 more... .pore complex .myelin sheath .nuclear membrane   + 8 more... 5 EBI-721550,EBI-3926629 GK     .glycerol-3-phosphate biosynthetic process .small molecule metabolic process .cellular lipid metabolic process   + 6 more... .ATP binding .glycerol kinase activity .extracellular exosome .cytosol .mitochondrial outer membrane   + 2 more... 6 EBI-721550,EBI-518675 STAT3     .negative regulation of neuron migration .interleukin-6-mediated signaling pathway .JAK-STAT cascade involved in growth hormone signaling pathway   + 35 more... .protein dimerization activity .transcription regulatory region DNA binding .protein phosphatase binding   + 9 more... .plasma membrane .cytosol .mitochondrial inner membrane   + 4 more... 7 EBI-721550,EBI-352602 MATR3     .posttranscriptional regulation of gene expression .poly(A) RNA binding .zinc ion binding .structural molecule activity .nucleotide binding .nuclear matrix .membrane .nucleoplasm .nuclear inner membrane 8 EBI-721550,EBI-748201 VASP     .protein homotetramerization .T cell receptor signaling pathway .cell junction assembly   + 4 more... .profilin binding .extracellular exosome .filopodium membrane .lamellipodium membrane   + 6 more... 9 EBI-721550,EBI-745859 CDKN2D     .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage .negative regulation of protein serine/threonine kinase activity .autophagic cell death   + 13 more... .protein kinase binding .cyclin-dependent protein serine/threonine kinase inhibitor activity .cytosol .cytoplasm .nucleus 10 EBI-721550,EBI-10172150 KRTAP10-5     .N/A .identical protein binding .keratin filament 11 EBI-721550,EBI-2341787 LONRF1     .N/A .zinc ion binding .ATP-dependent peptidase activity .N/A 12 EBI-721550,EBI-10290053 PGBD1     .N/A .scavenger receptor activity .sequence-specific DNA binding transcription factor activity .membrane .nucleus 13 EBI-721550,EBI-2687890 ANKIB1     .N/A .zinc ion binding .N/A 14 EBI-721550,EBI-310731 PLXND1     .semaphorin-plexin signaling pathway .dichotomous subdivision of terminal units involved in salivary gland branching .regulation of angiogenesis   + 8 more... .protein domain specific binding .semaphorin receptor activity .lamellipodium .integral component of plasma membrane .plasma membrane .intracellular EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 466 adrenal gland 425 bladder 167 blood 49 bone 69 bone marrow 20 brain 43 cervix 61 connective tissue 6 esophagus 148 eye 19 heart 67 intestine 43 kidney 14 larynx 42 liver 4 lung 50 lymph 67 lymph node 22 mammary gland 59 muscle 37 nerve 1351 ovary 128 pancreas 56 parathyroid 48 placenta 21 prostate 89 skin 66 stomach 52 testis 22 thymus 25 thyroid 171 trachea 57 uterus 112 Health State Tissues TPM* normal 51 adrenal tumor 237 bladder carcinoma 56 breast (mammary gland) tumor 42 cervical tumor 57 chondrosarcoma 289 colorectal tumor 26 esophageal tumor 173 gastrointestinal tumor 8 glioma 9 head and neck tumor 14 kidney tumor 58 leukemia 21 liver tumor 10 lung tumor 48 lymphoma 27 non-neoplasia 82 ovarian tumor 170 pancreatic tumor 28 primitive neuroectodermal tumor of the CNS 15 prostate cancer 48 skin tumor 63 soft tissue/muscle tissue tumor 7 uterine tumor 221 Developmental Stage Tissues TPM* adult 38 fetus 5 infant 42 juvenile 215 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 214.9 adrenal gland 564.1 appendix 89.6 bone marrow 19.7 cerebral cortex 26.4 colon 91.6 duodenum 32.6 esophagus 126 gallbladder 416.7 heart muscle 87.5 kidney 107 liver 45 lung 126 lymph node 51.2 ovary 625.3 pancreas 42.8 placenta 39.7 prostate 290.1 salivary gland 111.3 skin 5.6 small intestine 47.8 spleen 33.4 stomach 58.5 testis 26.4 thyroid gland 143.1 urinary bladder 289.2 RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Disease No. Disease Description Ref. 1 (*139139, gene) Nuclear receptor subfamily 4, group a, member 1; NR4A1 OMIM

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