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> Protein (NX_P22830)
Protein (NX_P22830)
Protein
Gene SymbolFECH to neXtProt (NX_P22830)
DescriptionFerrochelatase, mitochondrial
Chromosome18
Location18q21.31 (55215515 ~ 55254004) to Ensembl
Sequene Features : Isoforms 2, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to dexamethasone stimulus
.response to platinum ion
.iron ion homeostasis
  + 19 more...
.2 iron, 2 sulfur cluster binding
.iron-responsive element binding
.heme binding
  + 2 more...
.mitochondrial matrix
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 72 6
2014-09-19protein level
2 63 6
2014-05-27protein level
2 62 6
2014-02-25protein level
2 62 4
2013-12-09protein level
2 56 4
2013-11-01protein level
2 56 3
2013-09-12protein level
2 56 1
2013-08-17protein level
2 56 0
2013-07-15protein level
2 45 0
2013-06-11protein level
2 45 0
2013-02-12protein level
2 36 0
2012-12-20protein level
2 35 0
2012-10-30protein level
2 37 0
2012-10-07protein level
2 37 0
2012-08-24protein level
2 34 0
2012-07-28protein level
2 35 0
2012-06-08protein level
2 44 0
2012-05-07protein level
2 43 0
2012-04-10protein level
2 43 0
2012-01-13protein level
2 40 0
2011-12-20protein level
2 40 0
2011-11-11protein level
2 40 0
2011-08-23protein level
2 40 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P22830-1
0 21 0 47831.4245
NX_P22830-2
0 21 0 48593.7884
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites125
bladder33
blood81
bone41
bone marrow20
brain44
cervix185
connective tissue40
ear186
embryonic tissue42
esophagus99
eye47
heart100
intestine8
kidney99
larynx42
liver92
lung17
lymph node11
mammary gland13
mouth15
muscle9
ovary49
pancreas23
parathyroid97
placenta45
prostate253
skin47
spleen74
stomach10
testis52
thymus75
thyroid42
trachea77
umbilical cord435
uterus64
vascular38
Health State
TissuesTPM*
normal73
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor8
esophageal tumor57
gastrointestinal tumor59
germ cell tumor72
glioma37
head and neck tumor29
kidney tumor87
leukemia31
liver tumor41
lung tumor29
lymphoma27
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer452
retinoblastoma86
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult69
embryoid body57
blastocyst48
neonate225
fetus175
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland13.6
appendix8.8
bone marrow93.1
cerebral cortex14.5
colon12
duodenum9.9
esophagus14.2
gallbladder9.8
heart muscle19.9
kidney34.1
liver16
lung9.2
lymph node10.4
ovary10.6
pancreas4.5
placenta15.8
prostate16.9
salivary gland9.2
skin6.7
small intestine9
spleen10.4
stomach9.6
testis9
thyroid gland17.3
urinary bladder12.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Low
skin 2Low
small intestineMedium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#177000, phenotype) Protoporphyria, erythropoietic; EPPOMIM
2(*612386, gene) Ferrochelatase; FECHOMIM


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