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> Protein (NX_P23025)
Protein (NX_P23025)
Protein
Gene SymbolXPA to neXtProt (NX_P23025)
DescriptionDNA repair protein complementing XP-A cells
Chromosome9
Location9q22.33 (100437191 ~ 100459639) to Ensembl
Sequene Features : Isoforms 1, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.multicellular organism growth
.nucleotide-excision repair, DNA incision
.response to toxic substance
  + 6 more...
.metal ion binding
.protein homodimerization activity
.protein domain specific binding
.damaged DNA binding
.intercellular bridge
.Golgi apparatus
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 36 2
2014-09-19protein level
1 28 2
2014-05-27protein level
1 28 2
2014-02-25protein level
1 28 2
2013-12-09protein level
1 26 2
2013-11-01protein level
1 26 2
2013-09-12protein level
1 26 2
2013-08-17protein level
1 26 2
2013-07-15protein level
1 22 1
2013-06-11protein level
1 22 1
2013-02-12protein level
1 14 2
2012-12-20protein level
1 14 2
2012-10-30protein level
1 15 2
2012-10-07protein level
1 15 2
2012-08-24protein level
1 13 2
2012-07-28protein level
1 13 2
2012-06-08protein level
1 13 2
2012-05-07protein level
1 13 2
2012-04-10protein level
1 13 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 2
2011-08-23protein level
1 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23025-1
9 0 0 31347.6699
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295222,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
2 EBI-295222,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-295222,EBI-621404 RPA2  
  .regulation of DNA damage checkpoint
.regulation of cellular response to heat
.error-free translesion synthesis
  + 23 more...
.ubiquitin protein ligase binding
.protein phosphatase binding
.enzyme binding
  + 2 more...
.PML body
.DNA replication factor A complex
.nucleoplasm
  + 2 more...
4 EBI-295222,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
5 EBI-295222,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
6 EBI-295222,EBI-295232 XAB2  
  .transcription, DNA-templated
.nucleotide-excision repair
.transcription-coupled nucleotide-excision repair
  + 3 more...
.N/A .catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood8
bone27
brain10
connective tissue40
embryonic tissue18
eye14
heart33
intestine8
kidney4
liver9
lung29
mammary gland13
mouth15
ovary19
pancreas32
pituitary gland60
placenta17
prostate15
skin4
tonsil58
uterus12
vascular19
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor25
germ cell tumor15
glioma18
head and neck tumor7
non-neoplasia31
ovarian tumor26
pancreatic tumor19
prostate cancer19
skin tumor7
soft tissue/muscle tissue tumor47
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
blastocyst32
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.4
adrenal gland14.2
appendix11.1
bone marrow7.5
cerebral cortex12.6
colon11.4
duodenum14.7
esophagus14.4
gallbladder13
heart muscle9.4
kidney17.9
liver9.5
lung12.1
lymph node15.1
ovary13.2
pancreas5.2
placenta9.4
prostate17.5
salivary gland8.9
skin11.4
small intestine11.1
spleen11.6
stomach14.9
testis6.9
thyroid gland22.9
urinary bladder13.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumLow
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumLow
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#278700, phenotype) Xeroderma pigmentosum, complementation group a; XPAOMIM
2(*611153, gene) Xpa gene; XPAOMIM
3skin basal cell;skin squamous cell;melanoma;Xeroderma pigmentosum (A)CGP


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