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> Protein (NX_P23297)
Protein (NX_P23297)
Protein
Gene SymbolS100A1 to neXtProt (NX_P23297)
DescriptionProtein S100-A1
Chromosome1
Location1q21.3 (153600402 ~ 153604513) to Ensembl
Sequene Features : Isoforms 1, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of voltage-gated calcium channel activity
.intracellular signal transduction
.substantia nigra development
  + 2 more...
.ATPase binding
.S100 protein binding
.protein homodimerization activity
  + 2 more...
.protein complex
.neuron projection
.M band
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 12 1
2014-09-19protein level
1 10 1
2014-05-27protein level
1 10 1
2014-02-25protein level
1 10 1
2013-12-09protein level
1 7 1
2013-11-01protein level
1 6 1
2013-09-12protein level
1 6 1
2013-08-17protein level
1 6 1
2013-07-15protein level
1 5 1
2013-06-11protein level
1 5 1
2013-02-12protein level
1 1 0
2012-12-20protein level
1 1 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 0 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23297-1
3 0 0 10539.1138
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743686,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
2 EBI-743686,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-743686,EBI-743700 S100P  
  .endothelial cell migration
.response to organic substance
.calcium-dependent protein binding
.calcium ion binding
.magnesium ion binding
.extracellular exosome
.microvillus membrane
.cytoplasm
.nucleus
4 EBI-743686,EBI-752230 S100A2  
  .endothelial cell migration .identical protein binding
.calcium ion binding
.N/A
5 EBI-743686,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
6 EBI-743686,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone41
brain28
connective tissue13
embryonic tissue9
eye95
heart312
kidney9
larynx42
lung11
mammary gland92
muscle272
ovary49
placenta21
prostate5
skin132
testis2
thyroid64
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor96
chondrosarcoma36
germ cell tumor18
head and neck tumor29
ovarian tumor65
skin tumor223
Developmental Stage
TissuesTPM*
adult53
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue128.2
adrenal gland4.5
appendix4.4
cerebral cortex102.2
colon2.1
duodenum5.7
esophagus62.8
gallbladder2.4
heart muscle1532
kidney57.3
liver2.7
lung2.1
lymph node1.6
ovary1.1
pancreas6.1
placenta18.2
prostate38.8
salivary gland380.7
skin8
small intestine3.9
spleen1.5
stomach6.4
testis5.5
thyroid gland144.7
urinary bladder3.6
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonLow
duodenumLow
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderLow
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungLow
lymph nodeLow
nasopharynxLow
oral mucosaLow
pancreasLow
placentaMedium
rectumLow
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
small intestineLow
soft tissue 1Medium
soft tissue 2Low
stomach 1Medium
stomach 2Low
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176940, gene) S100 calcium-binding protein a1; S100A1OMIM


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