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> Protein (NX_P23368)
Protein (NX_P23368)
Protein
Gene SymbolME2 to neXtProt (NX_P23368)
DescriptionNAD-dependent malic enzyme, mitochondrial
Chromosome18
Location18q21.2 (48405419 ~ 48474691) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of NADP metabolic process
.malate metabolic process
.NAD binding
.metal ion binding
.electron carrier activity
  + 3 more...
.intracellular membrane-bounded organelle
.mitochondrial matrix
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 5
2014-09-19protein level
2 55 5
2014-05-27protein level
2 55 5
2014-02-25protein level
2 55 5
2013-12-09protein level
2 45 5
2013-11-01protein level
2 44 5
2013-09-12protein level
2 44 5
2013-08-17protein level
2 44 5
2013-07-15protein level
2 32 5
2013-06-11protein level
2 32 5
2013-02-12protein level
2 18 10
2012-12-20protein level
2 17 10
2012-10-30protein level
2 22 10
2012-10-07protein level
2 22 5
2012-08-24protein level
2 22 5
2012-07-28protein level
2 22 5
2012-06-08protein level
2 25 5
2012-05-07protein level
2 19 5
2012-04-10protein level
2 19 5
2012-01-13protein level
1 9 5
2011-12-20protein level
1 9 5
2011-11-11protein level
1 9 5
2011-08-23protein level
1 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23368-1
6 22 1 65401.5943
NX_P23368-2
1 22 1 53551.5823
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites75
blood40
bone55
bone marrow41
brain29
cervix41
connective tissue73
embryonic tissue51
eye62
heart55
intestine17
kidney18
liver38
lung35
lymph22
lymph node55
mammary gland46
muscle9
nerve64
ovary19
pancreas37
pharynx24
pituitary gland121
placenta17
prostate36
skin9
spleen18
stomach20
testis48
thymus25
trachea38
umbilical cord217
uterus34
Health State
TissuesTPM*
normal40
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor42
germ cell tumor45
glioma46
kidney tumor43
leukemia10
liver tumor52
lung tumor48
lymphoma83
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer38
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor87
uterine tumor44
Developmental Stage
TissuesTPM*
adult39
embryoid body28
blastocyst48
neonate96
fetus44
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.9
adrenal gland26.8
appendix35
bone marrow22.5
cerebral cortex21
colon42.7
duodenum44.7
esophagus17.3
gallbladder21.7
heart muscle39.3
kidney14.1
liver11
lung15.8
lymph node35.8
ovary14.6
pancreas11.3
placenta14.4
prostate20.2
salivary gland8.2
skin12.1
small intestine40.4
spleen42.6
stomach31.6
testis26.6
thyroid gland15.6
urinary bladder24.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleLow
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*154270, gene) Malic enzyme 2; ME2OMIM


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