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> Protein (NX_P23443)
Protein (NX_P23443)
Protein
Gene SymbolRPS6KB1 to neXtProt (NX_P23443)
DescriptionRibosomal protein S6 kinase beta-1
Chromosome17
Location17q23.1 (57970447 ~ 58027925) to Ensembl
Sequene Features : Isoforms 5, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.response to glucocorticoid
  + 37 more...
.peptide binding
.ATP binding
.protein serine/threonine/tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.neuron projection
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 46 9
2014-09-19protein level
5 34 9
2014-05-27protein level
4 34 10
2014-02-25protein level
2 34 11
2013-12-09protein level
2 30 11
2013-11-01protein level
2 30 11
2013-09-12protein level
2 30 11
2013-08-17protein level
2 30 11
2013-07-15protein level
2 19 10
2013-06-11protein level
2 19 10
2013-02-12protein level
2 9 18
2012-12-20protein level
2 9 18
2012-10-30protein level
2 10 18
2012-10-07protein level
2 10 9
2012-08-24protein level
2 10 9
2012-07-28protein level
2 10 9
2012-06-08protein level
2 17 9
2012-05-07protein level
2 14 9
2012-04-10protein level
2 14 9
2012-01-13protein level
2 12 9
2011-12-20protein level
2 12 9
2011-11-11protein level
2 12 8
2011-08-23protein level
2 12 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23443-1
0 20 1 59101.6478
NX_P23443-2
1 18 1 56153.2129
NX_P23443-3
1 18 1 52962.8803
NX_P23443-4
1 16 1 50983.6299
NX_P23443-5
0 19 1 56557.1466
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1775921,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
2 EBI-1775921,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
3 EBI-1775921,EBI-1052159 PPP2R2B  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.apoptotic process
.protein phosphatase type 2A regulator activity .cytoskeleton
.mitochondrial outer membrane
.mitochondrion
.protein phosphatase type 2A complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood49
bone13
bone marrow41
brain41
cervix41
connective tissue46
embryonic tissue42
esophagus49
eye38
heart44
intestine30
kidney28
liver34
lung32
lymph45
lymph node122
mammary gland178
mouth75
muscle65
nerve64
pancreas32
parathyroid97
placenta45
prostate26
salivary gland49
skin28
spleen18
stomach62
testis36
thyroid64
trachea57
uterus34
vascular77
Health State
TissuesTPM*
normal51
breast (mammary gland) tumor204
cervical tumor57
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor42
germ cell tumor53
glioma46
head and neck tumor52
kidney tumor29
leukemia42
liver tumor10
lung tumor38
lymphoma55
non-neoplasia20
pancreatic tumor57
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult52
embryoid body71
blastocyst32
neonate64
fetus95
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.9
adrenal gland13.9
appendix14.5
bone marrow16.1
cerebral cortex10.4
colon11.4
duodenum10.6
esophagus17.6
gallbladder11.3
heart muscle8.6
kidney10.1
liver9.1
lung10.6
lymph node15.8
ovary16
pancreas9.9
placenta17.1
prostate12.2
salivary gland8.2
skin10.1
small intestine9
spleen13.2
stomach12.2
testis8.4
thyroid gland14.8
urinary bladder14.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608938, gene) Ribosomal protein s6 kinase, 70-kd, 1; RPS6KB1OMIM


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