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> Protein (NX_P23458)
Protein (NX_P23458)
Protein
Gene SymbolJAK1 to neXtProt (NX_P23458)
DescriptionTyrosine-protein kinase JAK1
Chromosome1
Location1p31.3 (65298912 ~ 65432187) to Ensembl
Sequene Features : Isoforms 1, Variants 149, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
  + 12 more...
.protein phosphatase binding
.ATP binding
.growth hormone receptor binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.endomembrane system
.focal adhesion
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 149 10
2014-09-19protein level
1 113 10
2014-05-27protein level
1 113 10
2014-02-25protein level
1 100 10
2013-12-09protein level
1 85 9
2013-11-01protein level
1 82 7
2013-09-12protein level
1 82 7
2013-08-17protein level
1 82 7
2013-07-15protein level
1 47 6
2013-06-11protein level
1 47 6
2013-02-12protein level
1 16 8
2012-12-20protein level
1 16 8
2012-10-30protein level
1 23 8
2012-10-07protein level
1 23 8
2012-08-24protein level
1 10 8
2012-07-28protein level
1 10 8
2012-06-08protein level
1 13 8
2012-05-07protein level
1 13 8
2012-04-10protein level
1 13 8
2012-01-13protein level
1 7 8
2011-12-20protein level
1 7 8
2011-11-11protein level
1 7 8
2011-08-23protein level
1 7 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23458-1
58 0 2 133190.8745
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383438,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-1383438,EBI-958408 IFNAR2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.response to interferon-alpha
  + 6 more...
.type I interferon binding
.protein kinase binding
.type I interferon receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular space
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood57
bone153
bone marrow61
brain45
cervix144
connective tissue67
embryonic tissue46
esophagus49
eye43
heart67
intestine43
kidney118
larynx980
liver53
lung38
lymph203
lymph node367
mammary gland92
mouth105
muscle47
nerve128
ovary29
pancreas121
parathyroid48
pharynx24
placenta21
prostate47
skin71
stomach31
testis75
thymus50
thyroid300
tonsil235
trachea135
uterus86
vascular174
Health State
TissuesTPM*
normal78
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma156
colorectal tumor17
esophageal tumor57
gastrointestinal tumor25
germ cell tumor37
glioma37
head and neck tumor179
kidney tumor232
leukemia95
liver tumor114
lung tumor9
lymphoma166
non-neoplasia41
ovarian tumor78
pancreatic tumor95
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma21
skin tumor79
soft tissue/muscle tissue tumor239
uterine tumor33
Developmental Stage
TissuesTPM*
adult103
embryoid body100
neonate32
fetus50
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.9
adrenal gland34.9
appendix76.4
bone marrow37.3
cerebral cortex30.1
colon44.9
duodenum31.2
esophagus43.8
gallbladder65.6
heart muscle36.9
kidney38
liver38
lung54.6
lymph node95
ovary75.2
pancreas25.8
placenta45
prostate30.8
salivary gland23.1
skin54.2
small intestine37.2
spleen75.6
stomach46.8
testis48.1
thyroid gland42.6
urinary bladder70.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147795, gene) Janus kinase 1; JAK1OMIM
2acute lymphocytic leukemiaCGP


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