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> Protein (NX_P23497)
Protein (NX_P23497)
Protein
Gene SymbolSP100 to neXtProt (NX_P23497)
DescriptionNuclear autoantigen Sp-100
Chromosome2
Location2q37.1 (231280657 ~ 231408805) to Ensembl
Sequene Features : Isoforms 7, Variants 143, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 143 13
2014-09-19protein level
7 102 13
2014-05-27protein level
7 101 13
2014-02-25protein level
7 100 13
2013-12-09protein level
7 80 13
2013-11-01protein level
7 78 13
2013-09-12protein level
7 78 12
2013-08-17protein level
7 78 12
2013-07-15protein level
7 48 11
2013-06-11protein level
7 48 11
2013-02-12protein level
5 21 86
2012-12-20protein level
5 23 86
2012-10-30protein level
5 27 86
2012-10-07protein level
5 27 19
2012-08-24protein level
5 27 19
2012-07-28protein level
5 27 19
2012-06-08protein level
5 6 19
2012-05-07protein level
5 6 19
2012-04-10protein level
5 6 19
2012-01-13protein level
5 6 19
2011-12-20protein level
5 6 19
2011-11-11protein level
5 6 18
2011-08-23protein level
5 6 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23497-1
5 27 2 100353.8402
NX_P23497-2
0 21 2 53734.6923
NX_P23497-3
0 27 2 78125.5155
NX_P23497-4
12 27 2 101510.6506
NX_P23497-5
1 20 2 53079.7769
NX_P23497-6
0 20 2 50558.1659
NX_P23497-7
1 18 2 50000.9118
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751145,EBI-913209 ETS1  
  .response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
2 EBI-751145,EBI-77797 ACTN2  
  .negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
3 EBI-751145,EBI-474067 SUMO3  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.SUMO transferase activity .extracellular exosome
.PML body
.cytoplasm
  + 3 more...
4 EBI-751145,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
5 EBI-751145,EBI-6654703 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
6 EBI-751145,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
7 EBI-751145,EBI-712067 GIPC2  
  .N/A .N/A .extracellular exosome
.cytoplasm
8 EBI-751145,EBI-749432 DYRK2  
  .negative regulation of NFAT protein import into nucleus
.positive regulation of glycogen biosynthetic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 4 more...
.ubiquitin binding
.manganese ion binding
.ATP binding
  + 4 more...
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
  + 2 more...
9 EBI-751145,EBI-5458880 ZC2HC1A  
  .N/A .metal ion binding .N/A
10 EBI-751145,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
11 EBI-751145,EBI-2339650 CASP8AP2  
  .negative regulation of nucleic acid-templated transcription
.apoptotic signaling pathway
.cellular response to mechanical stimulus
  + 7 more...
.SUMO polymer binding
.peptidase activator activity involved in apoptotic process
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 3 more...
.PML body
.mitochondrion
.cytoplasm
.nucleus
12 EBI-751145,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
13 EBI-751145,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
14 EBI-751145,EBI-923653 DNMT3A  
  .C-5 methylation of cytosine
.cellular response to amino acid stimulus
.S-adenosylmethioninamine metabolic process
  + 15 more...
.DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
.metal ion binding
.unmethylated CpG binding
  + 5 more...
.nuclear matrix
.cytoplasm
.nuclear heterochromatin
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder401
blood130
bone69
bone marrow82
brain15
cervix144
connective tissue80
embryonic tissue18
esophagus99
eye52
heart55
intestine86
kidney99
liver53
lung86
lymph node133
mammary gland105
mouth45
ovary29
pancreas65
pharynx171
pituitary gland121
placenta67
prostate42
salivary gland49
skin104
spleen131
stomach146
testis13
thymus50
thyroid42
trachea77
uterus107
vascular135
Health State
TissuesTPM*
normal64
bladder carcinoma56
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma120
colorectal tumor79
esophageal tumor115
gastrointestinal tumor67
germ cell tumor18
head and neck tumor44
kidney tumor58
leukemia116
liver tumor72
lung tumor48
lymphoma27
non-neoplasia41
ovarian tumor13
pancreatic tumor76
primitive neuroectodermal tumor of the CNS23
prostate cancer28
skin tumor95
soft tissue/muscle tissue tumor95
uterine tumor99
Developmental Stage
TissuesTPM*
adult73
embryoid body42
blastocyst16
neonate96
fetus73
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.3
adrenal gland56.3
appendix91.7
bone marrow125
cerebral cortex8.5
colon44.3
duodenum56
esophagus38.1
gallbladder80
heart muscle47.7
kidney36.2
liver35.8
lung72
lymph node134.2
ovary50.8
pancreas26.9
placenta53.3
prostate40.3
salivary gland65.5
skin31
small intestine56.9
spleen112.9
stomach56.5
testis14.7
thyroid gland39.5
urinary bladder82.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Low
skin 2Low
small intestineHigh
soft tissue 1Low
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604585, gene) Nuclear body protein sp100; SP100OMIM


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