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> Protein (NX_P23511)
Protein (NX_P23511)
Protein
Gene SymbolNFYA to neXtProt (NX_P23511)
DescriptionNuclear transcription factor Y subunit alpha
Chromosome6
Location6p21.1 (41040684 ~ 41067715) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 2
2014-09-19protein level
2 29 2
2014-05-27protein level
2 29 2
2014-02-25protein level
2 28 2
2013-12-09protein level
2 23 2
2013-11-01protein level
2 21 2
2013-09-12protein level
2 21 2
2013-08-17protein level
2 21 2
2013-07-15protein level
2 12 1
2013-06-11protein level
2 12 1
2013-02-12protein level
2 3 2
2012-12-20protein level
2 3 2
2012-10-30protein level
2 3 2
2012-10-07protein level
2 3 1
2012-08-24protein level
2 3 1
2012-07-28protein level
2 3 1
2012-06-08protein level
2 4 1
2012-05-07protein level
2 2 1
2012-04-10protein level
2 2 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23511-1
1 2 0 36853.81
NX_P23511-2
1 2 0 33918.3187
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-389739,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-389739,EBI-389728 NFYB  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.repressing transcription factor binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
3 EBI-389739,EBI-389518 GTF2A1  
  .viral process
.gene expression
.transcription elongation from RNA polymerase II promoter
  + 3 more...
.protein heterodimerization activity
.TBP-class protein binding
.transcription factor binding
  + 2 more...
.cytoplasm
.transcription factor TFIIA complex
.nucleoplasm
4 EBI-389739,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
5 EBI-389739,EBI-398920 SRSF1  
  .cardiac muscle contraction
.regulation of mRNA splicing, via spliceosome
.regulation of mRNA stability
  + 13 more...
.poly(A) RNA binding
.mRNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.nuclear speck
  + 3 more...
6 EBI-389739,EBI-389755 NFYC  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.protein folding
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.transcription coactivator activity
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
7 EBI-389739,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
8 EBI-389739,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
9 EBI-389739,EBI-352851 LUC7L2  
  .mRNA splice site selection .poly(A) RNA binding
.enzyme binding
.mRNA binding
.nuclear speck
.U1 snRNP
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood57
bone27
bone marrow20
brain37
cervix20
connective tissue33
ear124
embryonic tissue51
eye43
heart22
intestine38
kidney14
liver4
lung26
lymph22
lymph node55
mammary gland66
mouth15
muscle28
nerve64
ovary19
pancreas23
pharynx24
pituitary gland121
placenta24
prostate26
skin4
stomach31
testis71
thymus37
thyroid21
uterus21
Health State
TissuesTPM*
normal38
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor42
germ cell tumor37
glioma27
head and neck tumor14
leukemia42
liver tumor10
lung tumor29
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer19
retinoblastoma86
skin tumor7
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult42
embryoid body114
blastocyst32
fetus59
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9
adrenal gland8
appendix13.7
bone marrow23.7
cerebral cortex10.9
colon11.1
duodenum8.5
esophagus9.5
gallbladder12.7
heart muscle5.5
kidney8.2
liver6.9
lung10.2
lymph node18.6
ovary17.1
pancreas4.9
placenta13.1
prostate11.5
salivary gland6.4
skin8.9
small intestine9.9
spleen12.1
stomach10.8
testis38.8
thyroid gland18.3
urinary bladder13.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*189903, gene) Nuclear transcription factor y, alpha; NFYAOMIM


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