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> Protein (NX_P23526)
Protein (NX_P23526)
Protein
Gene SymbolAHCY to neXtProt (NX_P23526)
DescriptionAdenosylhomocysteinase
Chromosome20
Location20q11.22 (32868074 ~ 32899608) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular nitrogen compound metabolic process
.S-adenosylmethionine cycle
  + 4 more...
.adenosylhomocysteinase activity .extracellular exosome
.melanosome
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 9
2014-09-19protein level
2 52 9
2014-05-27protein level
2 52 9
2014-02-25protein level
2 52 9
2013-12-09protein level
2 45 9
2013-11-01protein level
2 41 5
2013-09-12protein level
2 41 5
2013-08-17protein level
2 41 5
2013-07-15protein level
2 31 2
2013-06-11protein level
2 31 2
2013-02-12protein level
1 21 3
2012-12-20protein level
1 21 3
2012-10-30protein level
1 23 3
2012-10-07protein level
1 23 3
2012-08-24protein level
1 21 3
2012-07-28protein level
1 21 3
2012-06-08protein level
1 21 3
2012-05-07protein level
1 21 3
2012-04-10protein level
1 21 3
2012-01-13protein level
1 21 3
2011-12-20protein level
1 21 3
2011-11-11protein level
1 21 3
2011-08-23protein level
1 21 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P23526-1
2 22 0 47685.0687
NX_P23526-2
0 22 0 44629.4973
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053240,EBI-2838246 ANKRD40  
  .N/A .N/A .N/A
2 EBI-1053240,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
3 EBI-1053240,EBI-2874661 C1orf50  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland242
ascites326
bladder267
blood253
bone209
bone marrow492
brain282
cervix453
connective tissue107
embryonic tissue225
esophagus694
eye277
heart156
intestine275
kidney483
larynx42
liver355
lung226
lymph677
lymph node144
mammary gland271
mouth60
muscle235
nerve64
ovary374
pancreas135
parathyroid242
pharynx49
pituitary gland181
placenta268
prostate321
salivary gland394
skin488
spleen149
stomach292
testis222
thymus288
thyroid193
tonsil176
trachea96
umbilical cord217
uterus236
vascular290
Health State
TissuesTPM*
normal190
adrenal tumor237
breast (mammary gland) tumor397
cervical tumor579
chondrosarcoma72
colorectal tumor302
esophageal tumor811
gastrointestinal tumor455
germ cell tumor490
glioma475
head and neck tumor119
kidney tumor493
leukemia338
liver tumor666
lung tumor476
lymphoma637
non-neoplasia155
ovarian tumor380
pancreatic tumor209
primitive neuroectodermal tumor of the CNS889
prostate cancer337
retinoblastoma990
skin tumor630
soft tissue/muscle tissue tumor223
uterine tumor177
Developmental Stage
TissuesTPM*
adult212
embryoid body214
blastocyst309
neonate321
fetus186
infant552
juvenile989
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.2
adrenal gland36.2
appendix33.9
bone marrow36.9
cerebral cortex29
colon62.6
duodenum62.5
esophagus84.4
gallbladder34.7
heart muscle35.4
kidney139
liver70.1
lung26.9
lymph node44
ovary87.6
pancreas46.2
placenta43.2
prostate61
salivary gland42.4
skin27.4
small intestine48.1
spleen23.7
stomach46.5
testis74.1
thyroid gland104.8
urinary bladder48.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*180960, gene) S-adenosylhomocysteine hydrolase; AHCYOMIM
2(#613752, phenotype) Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiencyOMIM


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